Effects of chromium malate on glycometabolism,glycometabolism‐related enzyme levels and lipid metabolism in type 2 diabetic rats: A dose–response and curative effects study |
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Authors: | Weiwei Feng Guanghua Mao Qian Li Wei Wang Yao Chen Ting Zhao Fang Li Ye Zou Huiyu Wu Liuqing Yang Xiangyang Wu |
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Institution: | 1. School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, China;2. School of The Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu, China;3. School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, China;4. School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China;5. School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, China |
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Abstract: | Aims/IntroductionThe present study was designed to evaluate the effect of chromium malate on glycometabolism, glycometabolism-related enzyme levels and lipid metabolism in type 2 diabetic rats, and dose–response and curative effects.Materials and MethodsThe model of type 2 diabetes rats was developed, and daily treatment with chromium malate was given for 4 weeks. A rat enzyme-linked immunosorbent assay kit was used to assay glycometabolism, glycometabolism-related enzyme levels and lipid metabolism changes.ResultsThe results showed that the antihyperglycemic activity increased with administration of chromium malate in a dose–dependent manner. The serum insulin level, insulin resistance index and C-peptide level of the chromium malate groups at a dose of 17.5, 20.0 and 20.8 μg chromium/kg bodyweight were significantly lower than that of the model, chromium trichloride and chromium picolinate groups. The hepatic glycogen, glucose-6-phosphate dehydrogenase and glucokinase levels of the chromium malate groups at a dose of 17.5, 20.0 and 20.8 μg chromium/kg bodyweight were significantly higher than that of the model, chromium trichloride and chromium picolinate groups. Chromium malate at a dose of 20.0 and 20.8 μg chromium/kg bodyweight significantly changed the total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides levels compared with the chromium trichloride and chromium picolinate groups.ConclusionsThe results showed that chromium malate exhibits greater benefits in treating type 2 diabetes, and the curative effect of chromium malate is superior to chromium trichloride and chromium picolinate. |
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Keywords: | Chromium malate Glycometabolism Lipid metabolism |
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