先天性心脏病合并肺动脉高压患者体外循环围术期血浆内皮素水平的动态观察

应用放射免疫方法 ,对 2 2例左向右分流型先天性心脏病合并肺动脉高压患者 (肺高压组 )及 16例左向右分流先天性心脏病无肺高压患者 (无肺高压组 )体外循环心内直视手术围术期血浆内皮素水平进行了动态检测。结果发现 :两者体外循环心内手术围术期血浆内皮素水平显著升高 ;无肺高压组术后血浆内皮素水平迅速下降并于手术后 6h恢复至术前水平 ;肺高压组术后血浆内皮素水平下降缓慢 ,术后 48h尚未恢复至术前水平

Perioperative observation of plasma endothelin in patients with congenital heart disease with pulmonary hypertension underwent open heart surgery

To elucidate the correlation between endothelin(ET) and pulmonary hypertension, plasma ET was measured perioperatively by radioimmunassay in 22 patients with pulmonary hypertensiom who underwent open heart surgery(PH group)in comparison with 16 patients without pulmonary hypertension(non PH group)also underwent cardiopulmonary bypass(CPB) surgery. Results: Plasma ET was significantly increased during CPB in both group, Plasma ET decreased rapisly and returned to preoperative level within 6 hours after operation in the non PH group. In the PH group, however, plasma ET decreased slowly and did not return to preoperative level within 48 hours postoperation.