Anticomplementary activity of ergosterol peroxide fromNaematoloma fasciculare and reassignment of NMR data |
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| Authors: | Dong Seon Kim Nam-In Baek Sei Ryang Oh Keun Young Jung Im Seon Lee Jung Hee Kim Hyeong-Kyu Lee |
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| Affiliation: | (1) Kyunghee University, 449-701 Yongin, Korea;(2) Korea Research Institute of Bioscience & Biotechnology, KIST, Yusong P.O. Box 115, 305-600 Taejon, Korea |
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| Abstract: | A very high content (at least 0.23%) of ergosterol peroxide was isolated fromNaematoloma fasciculare Karst. Not only ergosterol peroxide but also ergosterol showed very strong anticomplementary activity on the classical pathway, the IC50 values being 5.0 μM and 1.0 μM, respectively. The1H and13C NMR data of ergosterol peroxide were revised and completely assigned by DEPT,1H-1H COSY, HMQC and HMBC correlations. |
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| Keywords: | Naematoloma fasciculare Anticomplementary activity Ergosterol Ergosterol peroxide 1H NMR 13C NMR HMBC |
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