Which cardiovascular risk factors matter in chronic kidney disease? |
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| Authors: | Colin Baigent Martin Landray |
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| Affiliation: | Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK. colin.baigent@ctsu.ox.ac.uk |
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| Abstract: | | Why measure risk factors for vascular disease? | Identifying cardiovascular risk factors among patients withchronic kidney disease (CKD) is potentially useful for two mainreasons. First, such risk factors may be used to predict thefuture risk of an event, which may help physicians to plan treatment.Second, they may be targets for intervention to prevent suchevents. It is now clear that a large number of risk factorsindependently predict the risk of cardiovascular outcomes amongdialysis patients [1] and among patients with lesser degreesof renal impairment [2]. But, although a risk score based onindependent risk factors can be assembled without particularregard to whether they are causal, treatments which modify aparticular risk factor will only be effective for the preventionof vascular disease if that risk factor is a cause of such disease. Limitations of dialysis studies for identifying causes of vascular disease | The starting point for identifying risk factors that might proveto be
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| Keywords: | blood pressure cholesterol epidemiology haematocrit randomized trials risk factors |
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