Pulmonary blastoma with germ cell (yolk sac) differentiation: report of two cases. |
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| Authors: | R J Siegel C Bueso-Ramos C Cohen M Koss |
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| Institution: | Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia. |
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| Abstract: | Pulmonary blastoma is a rare lung neoplasm of disputed histogenesis and variable biologic behavior. Typical cases contain both epithelial and mesenchymal tissues, and a variety of patterns of differentiation have been described. While expression of oncofetal antigens in these tumors has been noted rarely, a coexisting component of germ cell tumor has not been reported previously. We describe the clinical and pathologic features of two cases of pulmonary blastoma having alpha-fetoprotein production and histologic areas of yolk sac tumor. We also report the finding of immunohistochemical staining of fetal lung tissue for alpha-fetoprotein. |
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