Differentiation between Parkinson disease and other forms of Parkinsonism using support vector machine analysis of susceptibility-weighted imaging (SWI): initial results

Objectives

To diagnose Parkinson disease (PD) at the individual level using pattern recognition of brain susceptibility-weighted imaging (SWI).

Methods

We analysed brain SWI in 36 consecutive patients with Parkinsonism suggestive of PD who had (1) SWI at 3?T, (2) brain ¹²³I-ioflupane SPECT and (3) extensive neurological testing including follow-up (16 PD, 67.4?±?6.2?years, 11 female; 20 OTHER, a heterogeneous group of atypical Parkinsonism syndromes 65.2?±?12.5?years, 6 female). Analysis included group-level comparison of SWI values and individual-level support vector machine (SVM) analysis.

Results

At the group level, simple visual analysis yielded no differences between groups. However, the group-level analyses demonstrated increased SWI in the bilateral thalamus and left substantia nigra in PD patients versus other Parkinsonism. The inverse comparison yielded no supra-threshold clusters. At the individual level, SVM correctly classified PD patients with an accuracy above 86?%.

Conclusions

SVM pattern recognition of SWI data provides accurate discrimination of PD among patients with various forms of Parkinsonism at an individual level, despite the absence of visually detectable alterations. This pilot study warrants further confirmation in a larger cohort of PD patients and with different MR machines and MR parameters.

Key Points

? Magnetic resonance imaging data offers new insights into Parkinson??s disease ? Visual susceptibility-weighted imaging (SWI) analysis could not discriminate idiopathic from atypical PD ? However, support vector machine (SVM) analysis provided highly accurate detection of idiopathic PD ? SVM analysis may contribute to the clinical diagnosis of individual PD patients ? Such information can be readily obtained from routine MR data