| 红大戟中的1个新降碳三萜 |
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| 引用本文： | 赵 峰,马 丽,孙居锋,韩景田,王垣芳,张树平. 红大戟中的1个新降碳三萜[J]. 中草药, 2014, 45(1): 28-30 |
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| 作者姓名： | 赵 峰 马 丽 孙居锋 韩景田 王垣芳 张树平 |
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| 作者单位： | 1.滨州医学院药学院 山东省医药卫生天然药物重点实验室，山东 烟台 264003 2.烟台市口腔医院，山东 烟台 264001 |
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| 基金项目： | 国家自然科学基金资助项目（31170321）；山东省自然科学基金资助项目（ZR2011HL067）；滨州医学院校启动基金资助项目（BY2010KYQD12） |
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| 摘 要： | 目的 研究茜草科植物红大戟Knoxia valerianoides根的化学成分。方法 应用硅胶柱色谱、Sephadex LH-20柱色谱和半制备型反相高效液相色谱等方法进行分离和纯化，通过MS、NMR等波谱数据鉴定化合物的结构。结果 从红大戟干燥根的95%乙醇提取物中分离得到1个降碳三萜，结构鉴定为3-氧代-2, 19-二羟基-24-降乌苏-1, 4, 12-三烯-28-酸（1）。结论 化合物1为新化合物，命名为红大戟酸A。
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| 关 键 词： | 红大戟；茜草科；降碳三萜；3-氧代-2 19-二羟基-24-降乌苏-1 4 12-三烯-28-酸；红大戟酸A |
A new nor-triterpenoid from root tubers of Knoxia valerianoides |
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| ZHAO Feng,MA Li,SUN Ju-feng,HAN Jing-tian,WANG Yuan-fang,ZHANG Shu-ping. A new nor-triterpenoid from root tubers of Knoxia valerianoides[J]. Chinese Traditional and Herbal Drugs, 2014, 45(1): 28-30 |
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| Authors: | ZHAO Feng MA Li SUN Ju-feng HAN Jing-tian WANG Yuan-fang ZHANG Shu-ping |
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| Affiliation: | 1.Shandong Province Medical and Health Key Laboratory of Natural Medicines, Pharmacy Department, Binzhou Medical University, Yantai 264003, China 2.Yantai Stomatological Hospital, Yantai 264001, China |
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| Abstract: | Objective To investigate the chemical constituents from the root tubers of Knoxia valerianoides. Methods The constituents were isolated and purified by using a combination of chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, and reverse-phase HPLC. The structures were identified by spectroscopic analyses including MS, and NMR. Results A new nor-triterpenoid was isolated from the ethanol extract in the dried root rubers of K. valerianoides, and its structure was identified as 3-oxo-2, 19-dihydroxy-24-nor-urs-1, 4, 12-trien-28-oic acid (1). Conclusion Compound 1 is a new compound named knoxivalic acid A. |
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| Keywords: | Knoxia valerianoides Thorel ex Pitard Rubiaceae nor-triterpenoid 3-oxo-2, 19-dihydroxy-24-nor-urs-1, 4, 12-trien-28-oic acid knoxivalic acid A |
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