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Genetic analysis of 39 Y-STR loci in a Han population from Henan province,central China
Authors:Huang  Yanmei  Guo  Liwei  Wang  Mengge  Zhang  Cui  Kang  Lixia  Wang  Kejie  Ma  Yalei  Jiao  Huiyong  Li  Xi  Sun  Hongyu
Affiliation:1.Department of Forensic Genetics, School of Forensic Medicine, Xinxiang Medical University, 601 Jinsui Road, Hongqi District, Xinxiang City, 453003, Henan Province, People’s Republic of China
;2.Xinxiang Key Laboratory of Forensic Science Evidence, Xinxiang Medical University, Xinxiang City, People’s Republic of China
;3.Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu, 610041, China
;4.Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, No. 74 Zhongshan 2nd Road, Guangzhou, 510089, Guangdong, People’s Republic of China
;5.Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Sun Yat-Sen University, Guangzhou, People’s Republic of China
;
Abstract:

A total of 39 Y-chromosomal short tandem repeat (Y-STR) loci included in the advanced commercial six-dye multiplex system (AGCU Database Y30 kit) and a custom-designed four-dye multiplex system were investigated in 259 unrelated healthy Chinese males residing in Henan Province, central China. The haplotype diversity (HD) values were 0.99997 and 1.0000 for the six and four fluorescent-multiplex amplification systems, respectively. The discrimination capacity (DC) values were 0.9961 and 1.0000, respectively. When the 39 Y-STR loci were considered, 259 unique haplotypes were obtained in Henan Han individuals with both the haplotype diversity and discrimination capacity being 1.000. The gene diversity (GD) of 39 Y-STR loci in the studied group ranged from 0.3956 (DYS588) to 0.9990 (DYF403S1). Population comparisons between the Henan Han and 24 reference groups were performed. Both multidimensional scaling plots and phylogenetic analysis demonstrated that significant genetic differences existed between Henan Han and reference ethnic minorities of China, particularly the Tibetan, Uighur, and Mongolian populations. Moreover, the results indicated that 39 Y-STRs included in the two fluorescent-multiplex amplification systems are highly polymorphic and informative in the studied populations and can be employed as complementary tools for forensic application and human genetics research.

Keywords:
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