rOmpF and OMVs as efficient subunit vaccines against Salmonella enterica serovar Enteritidis infections in poultry farms |
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| Institution: | 1. Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, China;2. Jiangsu Key Lab of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, China;3. Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, China;1. College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;2. College of Animal Science and Technology, Zhe Jiang A&F University, Hangzhou 31130, China;1. Department of Bacteriology, Animal and Plant Health Agency, Addlestone, Surrey KT15 3NB, UK;2. Faculty of Health and Medical Sciences, AX Building, University of Surrey, Guildford, Surrey GU2 7XH, UK;3. Department of Pathology and Infectious Disease, School of Veterinary Medicine, Faculty of Health and Medical Sciences, Vet School Main Building, Daphne Jackson Road, University of Surrey, Guildford, GU2 7AL, UK;4. Department of Food and Nutrition, The University of Reading, Whiteknights Park, Reading, RG6 6AP, UK;1. Institute of Medical Immunology, Charité – Medical University Berlin, Germany;2. Bayer AG, Leverkusen, Germany |
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| Abstract: | Salmonella enterica serovar Enteritidis remains the most prevalent serotype causing human salmonellosis through the consumption of contaminated foods, especially poultry products. The development of a subunit vaccine against S. Enteritidis can not only protect chickens against Salmonella infection in the poultry industry but also cut the transmission sources. In this study, both the expressed recombinant outer membrane protein F (rOmpF) and extracted outer membrane vesicles (OMVs) were developed as subunit vaccines against S. Enteritidis challenge in chickens. Immunization with the subunit vaccine could induce not only antibody production but also strong cell-mediated immune response. Both rOmpF plus QuilA adjuvant and OMVs alone had highly protective efficacy against S. Enteritidis challenge and rapidly decreased the colonization of bacteria in chicken. These findings revealed the potential application of rOmpF and OMVs as subunit vaccines in the poultry industry. |
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| Keywords: | Subunit vaccine Outer membrane vesicles (OMVs) OmpF OmpC |
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