Clinicopathological study of involvement of the submandibular gland in oral squamous cell carcinoma |
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| Affiliation: | 1. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, 22 Zhong Guan Cun South Street, Beijing 100181, PR China;2. Department of Oral Pathology, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, 22 Zhong Guan Cun South Street, Beijing 100181, PR China;1. Dept. of Oral & Maxillofacial Surgery, Queen Victoria Hospital, East Grinstead, UK;2. Dept. of Otol Head & Neck Surgery, Queen Victoria Hospital, East Grinstead, UK;3. Facial Palsy Unit, Queen Victoria Hospital, East Grinstead, UK;1. Department of Pathology and Laboratory Medicine, Presbyterian University Hospital, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA;2. Department of Pathology and Laboratory Medicine, Emory University Hospital, Midtown 550 Peachtree Street, Atlanta, GA 30308, USA;1. Leeds University, Bradford Royal Infirmary;2. Bradford Royal Infirmary;3. Yorkshire and the Humber;1. Department of Head and Neck Surgery, National Kyushu Cancer Center, Notame 3-1-1, Minami-ku, Fukuoka 811-1395, Japan;2. Department of Pathology, National Kyushu Cancer Center, Notame 3-1-1, Minami-ku, Fukuoka 811-1395, Japan;1. Head and Neck Oncosurgery, Tata Memorial Hospital, Mumbai, India;2. Radiation Oncologist, Tata Memorial Hospital, Mumbai, India;3. Medical Oncologist, Tata Memorial Hospital, Mumbai, India |
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| Abstract: | Our purpose was to provide a pathological basis for preservation of the submandibular glands during neck dissection for oral squamous cell carcinoma (SCC) by investigating whether intraglandular lymph nodes exist in submandibular glands, and the modes of involvement of submandibular glands in oral SCC. We studied the records of 95 patients with oral SCC (other than that in the floor of the mouth) treated at our hospital from January 2017 to June 2018. The specimens of submandibular glands discarded after neck dissection were analysed, and serially sectioned. Sections 5 μm thick were obtained at 0.5 mm intervals and stained with haematoxylin and eosin for examination under light microscopy. A total of 116 specimens were obtained from the 95 patients, and about 5000 slides were evaluated. No intraglandular lymph nodes were detected in the submandibular glands. In the subgroup of patients whose primary tumours had extended into the floor of the mouth, four submandibular glands were involved by direct spread of the primary tumour. In the subgroup with metastases to level Ib lymph nodes, four submandibular glands were involved by extranodal extension from the metastatic nodes. No intraglandular lymph nodes or micrometastases were detected. We conclude that no intraglandular lymph nodes are present in submandibular glands, which may be involved by direct extension of the primary carcinoma or metastatic cervical lymph nodes with extranodal extension. Preservation of the submandibular glands during neck dissection seems to be feasible and safe in selected patients with oral SCC. |
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| Keywords: | submandibular gland neck dissection Oral squamous cell carcinoma |
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