Parental preferences for HPV vaccination in junior middle school girls in China: A discrete choice experiment |
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| Institution: | 1. Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi''an Jiaotong University, China;2. Center for Drug Safety and Policy Research, Xi''an Jiaotong University, China;3. Shaanxi Center for Health Reform and Development Research, Xi''an Jiaotong University, China;4. Research Institute for Drug Safety and Monitoring, Institute of Pharmaceutical Science and Technology, China’s Western Technological Innovation Harbor, Xi’an, China;1. Department of Immunization Program, Shanghai Municipal Centers for Disease Control & Prevention, NO. 1380, West Zhongshan Road, 200336, Shanghai, China;2. Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA;3. Department of Health Behavior & Health Education, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA;4. Department of Internal Medicine, Division of General Medicine, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA;5. Department of Internal Medicine, Division of Infectious Disease, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA;6. Susan B. Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA;1. EHESP French School of Public Health, Paris and Rennes, France;2. Université de Paris, LIRAES (EA 4470), Paris, France;3. Research Group for the Prevention of Occupational Infections in Healthcare Workers (GERES), Paris, France;4. Centre d’Investigation Clinique Cochin Pasteur CIC 1417, Hôpital Cochin, AP-HP, Paris, France;5. Haute autorité de santé (HAS), Commission technique des vaccinations (CTV), La Plaine Saint Denis, France;6. Unité des Virus Émergents (UVE: Aix-Marseille Univ – IRD 190 – Inserm 1207 – IHU Méditerranée Infection), Marseille, France;7. Institut Pasteur, Paris, France;8. CHU Ambroise Paré, Assistance Publique Hôpitaux de Paris (APHP,) Université Paris Saclay, France;1. Division of Behavioural Sciences, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;2. WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;1. Centre for Health Economics Research and Modelling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk (Antwerp), Belgium;2. Department of Economics & Flemish Research Foundation (FWO), University of Antwerp, Prinsstraat 13, 2000 Antwerp, Belgium;3. School of Economics, University of Amsterdam, PO Box 15867, 1001 NJ Amsterdam, the Netherlands;4. International Centre for Reproductive Health, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium;5. The South African Department of Science and Technology-National Research Foundation (DST-NRF) Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA), Stellenbosch University, Matieland, Stellenbosch 7602, South Africa;6. Center for Statistics, Hasselt University, Martelarenlaan 42, 3500 Hasselt, Belgium;7. Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium;8. Department of Global Health Faculty of Medicine and Health Sciences, Stellenbosch University, Matieland, Stellenbosch 7602, South Africa;9. School of Public Health and Community Medicine, The University of New South Wales, UNSW Medicine, NSW 2052, Australia;1. China Center for Health Development Studies, Peking University, Mailbox 505, 38 Xue Yuan Road, Haidian District, Beijing 100191, China;2. Center for Health Management and Policy, Shandong University, 44 Wenhua Xi Road, Jinan 250012, China;3. Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, 130 De Soto St, Pittsburgh, PA 15261, United States |
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| Abstract: | BackgroundCervical cancer is the second most common cancer in Chinese women. Human papillomavirus (HPV) vaccines have not yet been introduced in the Chinese national immunization program, and people vaccinate voluntarily at their own expense. Therefore, it is important to study the factors that could impact parents' decisions for HPV vaccination.ObjectiveTo quantify parental preferences regarding HPV vaccination for junior middle school-aged girls.MethodA discrete choice experiment (DCE) survey was conducted to assess parents' preferences for HPV vaccines. Data were collected from parents of girls aged 12–16 years in 11 middle schools of Shandong Province. We evaluated preferences for five attributes of HPV vaccination (vaccine effectiveness, protection duration, risk of side effects, cost, and vaccination location). Conditional logit regressions were adopted for analyses.Results995 parents completed valid DCE questions. All attributes influenced parents’ willingness to vaccinate. Comparatively highly educated parents preferred more on higher vaccine effectiveness and lower side effects risks while more intended to accept higher prices. Parents were willing to trade 2326.32 CNY for an increase in HPV vaccine effectiveness from 50% to 90%. Nearly 70% percent of the respondents were predicted to prefer multiple improvements in HPV vaccination (protection increased from 70% to 95%, duration increased from 9 years to 15 years, and vaccination location changed from vaccination center to school) to the base case.ConclusionVarious vaccine characteristics and implementation strategies influence respondents’ preferences. Health education with evidence-based information about HPV vaccines would help parents make informed decisions. The findings can also assist agencies responsible for HPV vaccination implementation and cervical cancer prevention in China in decisions regarding vaccination financing and vaccine approval. |
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| Keywords: | Cervical cancer HPV vaccines Discrete choice experiments Parental preferences Willingness to pay China |
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