首页 | 本学科首页   官方微博 | 高级检索  
     


Women who received varicella vaccine versus natural infection have different long-term T cell immunity but similar antibody levels
Affiliation:1. University of Rochester, Strong Memorial Hospital, Department of Obstetrics and Gynecology, United States;2. University of Rochester, Strong Memorial Hospital, Department of Vaccine Biology & Immunology, United States;1. Division of High-risk Pathogens, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, South Korea;2. Downstream Process Ⅱ, Research Center, GC Pharma, Yongin, South Korea;3. Department of Biostatistics, College of Medicine, Korea University, Seoul, South Korea;4. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea;5. Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea;1. Department of Medical Genetics, University of Antwerp/Antwerp University Hospital, Edegem, Belgium;2. AUDACIS, Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing, University of Antwerp, Antwerp, Belgium;3. Adrem Data Lab, Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium;4. Biomedical Informatics Research Network Antwerp (biomina), University of Antwerp, Antwerp, Belgium;5. Laboratory of Experimental Hematology (LEH), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium;6. Centre for Health Economics Research & Modeling Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium;7. Department of Laboratory Medicine, Antwerp University Hospital, Edegem, Belgium;8. Department of Paediatrics, Antwerp University Hospital, Edegem, Belgium;9. Centre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium;1. Internal Medicine – Nephrology & Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands;2. Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands;1. Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada;2. Public Health Agency of Canada, Ottawa, ON, Canada;3. School of Public Health, University of Alberta, Edmonton, Alberta, Canada;4. Alberta Health, Edmonton, Alberta, Canada;6. Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada;7. Provincial Laboratory for Public Health (ProvLab), Alberta, Canada
Abstract:BackgroundVaricella-zoster virus (VZV) infection during pregnancy is associated with serious fetal anomalies. The live-attenuated VZV vaccine was approved in 1995, so many vaccinated women are now of childbearing age. The question of long-term immunity to varicella is critical because breakthrough chickenpox can occur after vaccination.ObjectiveTo compare humoral and T cell immunity between women of childbearing age who were immunized by vaccination or chickenpox disease.Study designNon-pregnant females between 18 and 36 years old with a history of VZV immunization (n = 20) or prior chickenpox disease (n = 20) were recruited. IgG antibody titers and T cell responses were measured by flow cytometry-based methods in serum and peripheral blood, respectively.ResultsThere were no significant differences in median antibody titers between vaccinated and chickenpox groups (p = 0.34). The chickenpox group had significantly higher levels of VZV antigen-specific CD4 T cells (p = 0.004).ConclusionNatural infection induced higher VZV-specific T cell immune responses than vaccination.
Keywords:Varicella-zoster virus  Chickenpox  Pregnancy  Fetal anomalies  Vaccine  Flow cytometry  Humoral immunity  Cellular immunity
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号