Current status of virus-vectored vaccines against pathogens that affect poultry |
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| Affiliation: | 1. Centro de Virología Animal (CEVAN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Saladillo 2468 (C1440FFX), Ciudad Autónoma de Buenos Aires, Argentina;2. Instituto de Ciencia y Tecnología “Dr. Cesar Milstein”, CONICET, Saladillo 2468 (C1440FFX), Ciudad Autónoma de Buenos Aires, Argentina;1. Immunology Unit, University Hospital, Azienda Ospedaliera Universitaria Integrata Verona, Italy;2. Public Health Department, Udine Healthcare and University Integrated Trust, Udine, Italy;3. Dermatology Unit, Azienda Ospedaliera Universitaria Integrata Verona, Italy;1. North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, NC 27607, United States;2. Rollins Animal Disease Diagnostic Laboratory, 2101 Blue Ridge Road, Raleigh, NC 27607, United States;3. Zoetis-International Biodevices and Automation, 1040 Swabia Ct, Durham, NC 27703, United States;4. Boehringer Ingelheim Animal Health, Binger Strasse 173, 55216 Ingelheim, Germany;1. Department of Infection Biology, University of Liverpool, Leahurst Campus, Neston, Cheshire CH64 7TE, United Kingdom;2. Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra, 50, 40064 Ozzano dell’Emilia, BO, Italy;3. Department of Animal Medicine, Production and Health, University of Padua, Viale dell''Università, 16, 35020 Legnaro, PD, Italy;1. Clinic for Poultry, University of Veterinary Medicine, Bünteweg 17, 30559, Hannover, Germany;2. Boehringer Ingelheim, Veterinary Research Center GmbH Co. KG, Bemeroderstr. 31, 30559, Hannover, Germany;3. Lohmann Tierzucht GmbH, Am Seedeich 9-11, 27472, Cuxhaven, Germany |
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| Abstract: | The most effective strategies for the control of disease in poultry are vaccination and biosecurity. Vaccines useful against pathogens affecting poultry must be safe, effective with a single dose, inexpensive, applicable by mass vaccination methods, and able to induce a protective immune response in the presence of maternal antibodies. Viral vector meet some of these characteristics and if the attenuated virus used as vector infects birds, the vaccine will have the advantage of being bivalent. Thus, viral vectors are currently a tool of choice for the development of new poultry vaccines. This review describes the main viruses used as vectors for the delivery and in vivo expression of antigens of poultry pathogens. It also presents the methodologies most frequently used to obtain recombinant viral vectors and summarizes the state-of-the-art related to vectored vaccines in poultry (some of them currently licensed), the pathogens targeted and their antigens, and the ability of these vaccines to induce an effective immune response. Finally, the review discusses the results of a few studies comparing recombinant viral vector vaccines and live-attenuated vaccines in vaccine matching challenges, and mentions strategies and future researches that can help to improve the efficacy of vectored vaccines in poultry birds. |
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| Keywords: | Poxvirus Adenovirus Marek’s disease virus Turkey herpesvirus Newcastle disease virus Recombinant vaccines for poultry |
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