Involvement of PI3K/Akt pathway in prostate cancer--potential strategies for developing targeted therapies |
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| Authors: | Pommery Nicole Hénichart Jean-Pierre |
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| Affiliation: | Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, Lille, France. henicha@pharma.univ-lille2.fr |
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| Abstract: | This review presents some therapeutic interventions actually considered in prostate cancer therapy to compensate constitutive activation of the PI3K/Akt signalling pathway induced, particularly, by mutations of PTEN gene. Special emphasis is placed on applicability of EGF-R tyrosine kinase, COX-2, PDK-1, mTOR and farnesyltransferase inhibitors. |
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