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18F-FDG-PET/CT predicts survival in hypopharyngeal squamous cell carcinoma
Authors:Hidenori Suzuki  Katsuhiko Kato  Yasushi Fujimoto  Yoshiyuki Itoh  Mariko Hiramatsu  Takashi Maruo  Shinji Naganawa  Yasuhisa Hasegawa  Tsutomu Nakashima
Institution:1. Department of Head and Neck Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan
2. Department of Radiological Technology of Health Sciences, Nagoya University School of Health Sciences, Nagoya, Japan
3. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
4. Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Abstract:

Objectives

We investigated the relationship between overall survival of patients and pretreatment 18F]-2-fluorodeoxyglucose (18F-FDG) uptake, assessed by positron emission tomography combined with computed tomography (PET/CT) in hypopharyngeal squamous cell carcinoma.

Methods

Thirty-one patients who were newly diagnosed as resectable hypopharyngeal squamous cell carcinoma underwent pretreatment 18F-FDG-PET/CT. We used the maximum standardized uptake value (SUVmax) as 18F-FDG uptake. Overall survival rate was calculated by the Kaplan–Meier method.

Results

The median SUVmax was 11.53 (range 2.49–22.33). Patients with SUVmax ≥ 13 significantly exhibited shorter overall survival in univariate analysis (p < 0.01). Moreover, by Cox proportional hazards model of multivariate analysis, SUVmax ≥ 13 was a significant prognostic factor independent of clinical T and N classification, and treatment group (p < 0.02).

Conclusions

These results suggested that SUVmax obtained by pretreatment 18F-FDG PET/CT assessment is an important prognostic factor in patients with hypopharyngeal squamous cell carcinoma.
Keywords:
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