饮酒对慢性肝炎肝纤维化指标及转归的影响

目的:探讨饮酒对慢性肝炎肝纤维化指标及治疗效果的影响。方法:选择有饮酒史慢性肝炎患者76例(观察组),研究分析其血清肝纤维化指标、门静脉直径及治疗效果与非饮酒患者(对照组)的差异。结果:具有饮酒史的慢性肝炎患者血清肝纤维化指标透明质酸(HA)和层连蛋白(LN)明显高于非饮酒患者(295.33±49.55,149.85±36.04,P<0.001;163.21±16.15,136.63±11.76,P<0.001),观察组患者门静脉平均直径大于对照组〔(1.32±0.16)cm,(1.22±0.24)cm,P<0.05〕,观察组治愈好转率明显低于对照组(P<0.05)。结论:饮酒的慢性肝炎患者肝脏纤维化进程快、肝脏储备能力较差,对治疗反应较差,病死率较高。

Effect to liver fibrosis and prognosis of alcohol addict in chronic hepatitis

Objective:To explore the effect of treatment and prognosis of chronic hepatitis with alcohol addict.Methods:69 cases of alcohol addicts with chronic hepatitis were selected.The difference of liver fibrosis mark,hyaluronic acid (HA) and laminin (LN),the portal vein diameter and treatment effect were studied between alcohol addict group and control.Results:The quantity of HA,LN in serum of alcohol addicts were higher than that of control(295.33±49.55, 149.85±36.04,P<0.001;163.21±16.15, 136.63±11.76,P<0.001) and the average diameter of portal vein was wide than that of control group 〔(1.32±0.16) cm,(1.22±0.24) cm,P<0.05〕.The heal ratio of alcohol addicts group was lower than that of control group (P<0.05).Conclusion:The chronic hepatitis with alcohol addict become liver fibrosis more quickly,have lower repertory strength,poor therapy effect and high ratio of death than control group.