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Migrating ability of tumor cells treated with immune sera
Authors:K. A. Lebedev  D. R. Kaulen  V. V. Khorobrykh  G. N. D'yakov  A. V. Simonova
Abstract:The action of antitumor sera (ATS) on the adhesive properties of L cells and of Ehrlich's ascites carcinoma cells was studied. The ability of the tumor cells to adhere to plastic and glass and to form rosettes with sheep's red blood cells was reduced after treatment with immune serum and, when injected into mice, fewer of these cells were held up in the lungs, spleen, and liver. The results show that antibodies may play an essential role in the metastasization of tumor cells.Research Center, N. I. Pirogov Second Moscow Medical Institute. N. F. Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR P. A. Vershilova.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 12, pp. 712–714, December, 1977.
Keywords:adhesion  migration of cells  tumor cells  metastasization of tumors  antibodies
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