猪急性心肌梗死后骨髓干细胞自体移植对左心室重构的影响

目的 观察猪心肌梗死(心梗)后冠脉内注射移植骨髓干细胞时心室重_构的影响.方法 前降支球囊封堵法成功建立10头猪急性心肌梗死动物模型,随机均分为安慰刺组和移植组.造模1周后,移植组冠脉内注自体骨髓干细胞,安慰剂组注射1640培养基作为对照.造模前、造模后1周、造模后3月分别行心脏超声和SPECT检查,对比观察骨髓干细胞自体移植对急性心梗后左室重构的影响.结果与安慰剂组相比,移植组造模后3月时左室舒张内径更小,心尖室壁厚度更大,左室舒张末期容积更小,射血分数更高.结论 骨髓干细胞自体移植能有效减轻急性心肌梗死后左室重构.

Effects of bone marrow stem cells autologous transplantation on ventricular remodeling after acute myocardial infarction

Objective To investigate the effects of bone marrow stem cells autologous transplantation on left ventricular remodeling after acute myocardial infarction. Methods Acute myocardial infarction models were successfully established in 10 swines, which were ran-dom divided into two groups, placebo group and trasplantation group. One week after operation, bone marrow stem cells autologous transplan-tation was performed, and control group was administrated with placebo. B-ultrasound and emission computed tomography aexaminations were performed to assess the left ventrieular end diastolic dimension, left ventricular tip wall thickness, left ventricular end diastolic volume and left ventricula ejection fraction before operation, one week, three months after acute myocardial infarction. Results Compared with that of control group, three months after acute myocardial infarction, transplantation group witnessed smaller left ventricular end diastolic dimension, thicker left ventricular tip wall, smaller left ventricular end diastolic volume and higher left ventricular ejection fraction. Conclusions Bone marrow autologous transplantation after acute myocardial infarction can alleviate left ventricular remodeling.