| 放射性肺损伤大白兔模型的构建及多层螺旋CT的评价 |
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| 引用本文： | 丁文,刘佰弘,李鑫欣. 放射性肺损伤大白兔模型的构建及多层螺旋CT的评价[J]. 医学综述, 2008, 14(22): 3503-3506 |
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| 作者姓名： | 丁文 刘佰弘 李鑫欣 |
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| 作者单位： | 山东省文登整骨医院骨伤研究所,山东,文登,264400 |
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| 摘 要： | 目的研究大白兔放射性肺损伤影像学模型的制作方法,结合病理学改变评价多层螺旋CT(MSCT)对放射性肺损伤的早期诊断价值。方法40只新西兰大白兔随机分为照射组和对照组,分别以30、40、50Gy剂量行右肺2/3面积照射建立肺损伤模型,照射后第2、4、6、8周分别行MSCT检查并作pulmo曲线分析。结果动物模型可安全建立,MSCT能够清晰显示大白兔放射性肺损伤毛玻璃改变、斑片状及纤维索条影。随着照射剂量的增大,肺泡腔厚度增厚明显,尤以50Gy照射损伤最为明显与对照组比较,各时间点分别均有统计学意义(P<0.05或P<0.01)。且各时间点右肺密度显著高于左肺。结论大白兔右肺一次30、40、50Gy照射可以制作放射性肺损伤的急性模型,且50Gy照射损伤最为明显。MSCT可以早期诊断放射性肺损伤。
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| 关 键 词： | 肺 放射损伤 大白兔 体层摄影术 X线计算机 |
Setting up of Radiation Induced Lung Injury in Rabbit Model and Evaluation of MSCT |
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| DING Wen,LIU Ba-hong,LI Xin-xin. Setting up of Radiation Induced Lung Injury in Rabbit Model and Evaluation of MSCT[J]. Medical Recapitulate, 2008, 14(22): 3503-3506 |
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| Authors: | DING Wen LIU Ba-hong LI Xin-xin |
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| Affiliation: | DING Wen,LIU Ba-hong,LI Xin-xin.(Department of Orthopaedics , Traumatology,Wendeng Orthopaedic Traumatic Hospital,Wendeng 264400,China) |
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| Abstract: | Objective To construct rabbit model of radiation induced lung injury,combine the pathologic changes and to assess diagnostic value of MSCT in the early phase of radiation induced lung injury.Methods Forty rabbits were divided into one normal control group and three experimental groups randomly,and the experimental groups received dose of 30,40,50 Gy to the right lung.image of MSCT and analyze of pulmo curve were obtained at 2,4,6,8 weeks.Result Animal model of security can be established MSCT findings inclu... |
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| Keywords: | Lung Radiation induced injury Rabbit Multiple spiral computed tomography |
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