电针结合中频对腰神经根受压模型大鼠抗炎镇痛的作用

目的:探讨电针结合中频治疗腰神经根受压的效应及作用机制.方法:将72只SD大鼠随机分为正常组、假手术组、模型组、电针组、中频组和电针加中频组,每组12只.后4组经手术复制腰神经根受压模型.正常组、假手术组、模型组不做任何治疗,电针组进行电针治疗,穴取"夹脊""环跳"等,中频组采用中频治疗,穴取"夹脊""环跳",电针加中频组先后进行电针与中频治疗,取穴及治疗时间与上两组相同.所有治疗均于造模成功后第5天开始,每日1次,连续治疗14 d.观察治疗前后大鼠患肢大体观,检测治疗后血浆血栓素B2(TXB 2)、前列环素F1α(PGF1α)含量,并通过光镜观察受压神经根局部的病理变化.结果:与治疗前相比,3个治疗组均能明显降低模型大鼠患肢神经功能评分(均P<0.01).治疗后,与模型组相比,电针组及电针加中频组TXB 2下降明显(均P<0.01),电针加中频组PGF1α上升明显(P<0.01),3组的TXB 2/PGF1α比值均得到了良性调整(均P<0.01),同时电针组、电针加中频组的病理评分改善明显(均P<0.01).结论:电针结合中频治疗对腰神经根受压模型大鼠具有抗炎镇痛的作用;降低TXB 2、升高PGF1α、维持两者的动态平衡,从而改善微循环状态是其作用机制之一.

Experimental study on anti-inflammatory and analgesic effects of electroacupuncture combined with medium frequency therapy in model rats with lumbar nerve root compression

Objective To explore the effects and mechanism of electroacupuncture combined with medium frequency therapy on lumbar nerve root compression.Methods Seventy-two Sprague-Dawley(SD) rats were randomly divided into a normal group,a sham operation group,a model group,an electroacupuncture group(EA group),a medium frequency group(MF group) and an electroacupuncture combined with medium frequency group(EA+MF group),twelve rats in each group.Models were established by surgery except the normal group and the sham o...