小细胞肺癌Notch-1表达相关性及预后分析

目的 研究Notch-1抗体在小细胞肺癌(SCLC)及非小细胞肺癌(NSCLC)中表达的临床意义,并分析其对预后的影响.方法 采用SP免疫组化分别检测43例SCLC及40例NSCLC患者癌组织Notch-1抗体的表达,分析Notch-1抗体表达缺失与SCLC临床病理特征、淋巴结转移及患者预后的关系.结果 Notch-1抗体在SCLC中的表达率为20.93％( 9/43),而在NSCLC中则高达65.00％( 26/40).Notch-1抗体在SCLC中的表达与临床分期及有无淋巴结转移相关(分别x2=5.42和P＜0.05,x2=4.88,P＜0.05),但与患者年龄、性别、肿瘤位置、肿瘤大小无关(P均＞0.05);与NSCLC比较,Notch-1抗体在SCLC中的表达差异有统计学意义(x2 =16.50,P＜0.05).Kaplan-Meier生存分析证实Notch-1抗体阳性患者5年生存率较阴性患者为高(x2=19.87,P＜0.05);Cox比例风险回归分析显示Notch-1抗体阳性可明显降低SCLC患者的死亡风险.结论 Notch-1抗体在SCLC与NSCLC中的阳性表达率有明显差异,与SCLC临床分期、淋巴结转移及预后有关.因此,Notch-1表达在SCLC的诊断及预后评估方面具有较好的应用价值. .

The correlation of notch-1 expression and comprehensive analysis with prognosis in small cell lung cancer

Objective To investigate the clinical significance of Notch-1 expression in small cell lung cancer(SCLC) and non-small cell lung cancer(NSCLC),and analyze the role of it in prognosis.Methods SP immunohistochemistry was used to detect the expression of Notch-1 antibody in 43 of SCLC and 40 of NSCLC tissues.Further analysis was carried out to interpret the association of Notch-1 antibody expression with clinicopathological features,lymph node metastasis and prognosis in SCLC.Results The positive rate of Notch-1 expression was 20.93％ ( 9/43 ) in SCLC,while 65.00％ ( 26/40 ) in NSCLC.The expression of Notch-1 antibody was associated with clinical stage and lymph node metastasis ( x2 =5.42,P ＜ 0.05 ; x2 =4.88,P ＜ 0.05respectively),but was not associated with age,sex,tumor location,tumor size ( Ps ＞ 0.05 ).Compared with NSCLC,the expression rates of Notch-1 antibody were significantly higher in SCLC ( x2 =16.50,P ＜ 0.05 ).Kaplan-Meier survival analysis indicated that the survival time of patients with positive Notch-1 expression was significantly longer than that of patients with negative staining( x2 =19.87,P ＜ 0.05 ).Cox regression analysis showed that Notch-1 antibody could significantly reduce the risk of death in patients with SCLC.Conclusion The positive expressions of Notch-1 were significantly different in SCLC and NSCLC,which linked to the clinicalstage,lymph node metastasis and poor prognosis.Accordingly,the expression of Notch-1 may have good value in diagnosis and prognosis.