慢性胃炎和十二指肠球部溃疡红细胞免疫功能的变化

目的 探讨胃疾病与红细胞免疫功能变化的研究.方法 采用花环法测定红细胞C3b受体花环率(RBCC3bRR)及免疫复合物花环率(RBCICR),对103例慢性胃炎(慢性胃炎组)和75例十二脂肠球部溃疡患者(十二指肠球部溃疡组)及30名健康者(正常对照组)进行红细胞免疫功能检测.结果 正常对照组、慢性胃炎组、十二指肠球部溃疡组RBCC3bRR分别为(20.83±5.16)％、(16.26±5.17)％、(13.65±5.19)％,RBCICR分别为(7.63±4.09)％、(10.59±4.45)％、(10.04±4.13)％.2项指标慢性胃炎组和十二指肠球部溃疡组均低于正常对照组(t分别为4.963、6.070,P均＜0.01),RBCICR分别高于正常对照组(t分别为3.262、3.456,P＜0.05或P＜0.01).HP阴性慢性胃炎与HP阴性十二指肠球部溃疡、HP阳性慢性胃炎与HP阳性十二指肠球部溃疡分别比较RBCC3hRR和RBCICR差异均无统计学意义(P均＞0.05);慢性胃炎及十二指肠球部溃疡HP阳性RBCC3bRR明显低于HP阴性者(P＜0.05或P＜0.01),RBCICR明显高于HiP阴性者(P均＜0.01),HP根除后慢性胃炎和十二指肠球部溃疡患者RBCC3bRR,分别较治疗前明显升高(P＜0.05或P＜0.01).RBCICR分别较治疗前明显降低(P均＜0.01).结论 HP感染、慢性胃炎、十二指肠溃疡均可降低红细胞免疫功能.

Immune function of red blood cells in chronic gastritis and duodenal ulcer disease

Objective To explore changes of the immune function of red blood cells in gastric disease.Methods RBC C3b receptor rosette(RBCC3bRR)and RBC immune complex rosette(RBCICR)were tested in chronic gastritis group(n =103),duodenal ball ulcer group(n =75)and control group(n =30)to evaluate the immune function of RBC.Results RBCC3bRR were(20.83 ± 5.16)％ in the control group,(16.26 ±5.17)％ in the chronic gastritis group and(13.65 ± 5.19)％ in the duodenal ball ulcer group.RBCICR were respectively(7.63 ± 4.09)％,(10.59 + 4.45)％ and(10.04 ± 4.13)％ in these three groups.RBCC3bRR of chronic gastritis and duodenal ball ulcer were lower than control group(P ＜0.0l),while RBCICR were higher than normal control group(P ＜0.05 and P ＜0.01 respectively).There was no significant difference on RBCC3bRR and RBCICR between HP negative chronic gastritis and HP negative duodenal ball ulcer and between HP positive chronic gastritis and HP positive duodenal ball ulcer(P ＞ 0.05).RBCC3bRR of HP positive chronic gastritis and duodenal ball ulcer was significantly lower than that of HP negative(P ＜ 0.05and P ＜ 0.01 respectively),RBCICR significantly higher than that of HP negative(P ＜ 0.01).After HP eradication,RBCC3bRR of patients with chronic gastritis and duodenal ball ulcer was increased significantly (P＜0.05 and P ＜ 0.01 respectively).RBCICR was significantly lower than before treatment(P ＜ 0.01).Conclusion HP infection,chronic gastritis and duodenal ulcer can decrease the immune function of red blood cells.