2型糖尿病合并乳腺癌30例临床分析

目的 研究2型糖尿病合并乳腺癌患者与单纯乳腺癌患者一般情况与临床相关病理指标之间的差异,探讨糖尿病与乳腺癌之间的相关性.方法 采用病例对照的方法分析比较同时期住院的2型糖尿病合并乳腺癌患者(2型糖尿病合并乳腺癌组)以及单纯乳腺癌患者(单纯乳腺癌组)之间的临床一般情况、相关病理学指标之间的差异.结果 2型糖尿病合并乳腺癌组平均年龄、空腹血糖、BMI以及甘油三酯高于单纯乳腺癌组分别为(58.4±7.80)岁与(51.6+9.90)岁,t=2.968,P=0.004;(8.15±2.80)mmol/L与(5.13±0.63)mmol/L,t =5.757,P=0.000;(27.72±3.47)mmol/L与(24.15±4.95)mmol/L,t=3.235,P=0.002;(2.36±1.18)mmol/L与(1.32±0.59)mmol/L,t=4.330,P=0.000],高密度脂蛋白胆固醇低于单纯乳腺癌组(1.39±0.20)mmol/L与(1.50±0.24)mmol/L,t =2.000,P=0.05],而总胆固醇以及低密度脂蛋白胆固醇在2组的比较中差异无统计学意义分别为(4.89±1.16)mmol/L与(4.79 ±0.85)mmol/L,t=0.396,P=0.693;(3.02±0.90)mmol/L与(2.97 ±0.61)mmol/L,t=0.255,P=0.800];合并糖尿病患者绝经患者多(X2=11.835,P=0.001);糖尿病组Her-2的表达率高于单纯乳腺癌组,差异具有统计学意义分别为76.7％(23/30),50.8％(33/65),x2=5.689,P=0.017].结论 2型糖尿病合并乳腺癌患者较单纯乳腺癌患者年龄更大且绝经患者多,体重指数较高,预后较差,所以合并有糖尿病的乳腺癌患者更应选择合理的治疗方案.

Analysis of clinical data in breast cancer patients with type 2 diabetes

Objective To investigate differences of ctinicopathologic features in breast cancer patients with or without Type 2 Diabetes Mellitus(DM).Methods The general conditions and elinicopathologic features of the hospitalized breast cancer patients with or without type 2 diabetes were analyzed using a case-control study.Results The average age,fasting blood-glucose,BMI and TG were(58.4 ± 7.80),(8.15 ± 2.80)mmol/L,(27.72 ± 3.47)mmol/L and(2.36 ± 1.18)mmol/L in patients with DM,and(51.6 ± 9.90),(5.13 ±0.63)mmol/L,(24.15 ± 4.95)mmol/L and(1.32 ± 0.59)mmol/L in patients without DM.There were significantdifference between the two groups(t =2.968,P =0.004; t =5.757,P ＜ 0.001 ; t =3.235,P =0.002; t =4.330,P ＜0.001,respectively).HDL-C in patients with DM was(1.39 +0.20)mmol/L,which was significantly lower than that of(1.50 ± 0.24)mmol/L in patients without DM(t =2.000,P =0.05).TC and LDL-C was(4.89 ± 1.16)mmol/L and(3.02 ±0.90)mmol/L in patients with DM,which were not significantly different with those of(4.79 ±0.85)mmol/L and(2.97 +0.61)mmol/L in patients without DM(t =0.396,P =0.693,and t =0.255,P =0.800,respectively).More patients were in the menopausal status in breast cancer patients with Type 2 DM compared to the other group(x2 =11.835,P =0.001).The expression of Her-2 was 76.7％(23/30)in breast cancer patients with Type 2 DM,which was significantly higher than that of 50.8％(33/65)in patients without DM(x2 =5.689,P =0.017).Conclusion The average age was higher in breast cancer patients with Type 2 DM and most of them were in their menopausal status,furthermore the higher body mass index and worse prognosis were observed in this group,so the breast cancer patients with diabetes should choose the more reasonable treatment.