手足口病患儿血清中IL-6IL-10IL-13及IL-17的变化及临床意义

目的 探讨手足口病患儿血清中IL-6 IL-10 IL-13及IL-17的变化及临床意义.方法 采用酶联免疫吸附实验（ELISA）抗体夹心法测定46例手足口病患儿急性期、恢复期及40例健康体检儿童血清IL-6、IL-10、IL-13、IL-17的含量,对手足口病患儿急性期、恢复期进行比较,同时对其中重症患儿、普通患儿进行比较,用统计软件进行统计学分析.结果 急性期重症组与普通组IL-6、IL-10、IL-13及IL-17水平均明显升高,与对照组比较有统计学意义（P＜0.01）,重症组与普通组比较有统计学意义（P＜0.01）.恢复期重症组与普通组IL-6、IL-17较急性期下降,普通组与对照组比较无统计学意义（P＞0.05）,而重症组与对照组比较有统计学意义（P＜0.01）,但是IL-10、IL-13重症组和普通组均较急性期下降,但仍高于对照组,两组与对照组比较有统计学意义（P＜0.01）.结论 炎症因子IL-6、IL-17在急性期水平显著升高,而抑制性细胞因子IL-10、IL-13水平升高持续到恢复期.

Changes and clinical significance of serum IL-6,IL-10,IL-13 and IL-17 levels in children with hand-foot-mouth disease

Objective To study the changes and clinical significance of serum IL-6,IL-10,IL-13,IL-17 levels in the children with hand-foot-mouth disease （HFMD）.Methods The serum concentration of IL-6,IL-10,IL-13,IL-17 in 46 case of HFMD children with acute stage and recovery stage and 40 cases of healthy controls were measured by ELISA.The data was analyzed by statistical SPSS software.Results In acute stage,the levels of IL-6,IL-10,IL-13,IL-17 in children of severe HFMD were higher than those in general children （P〈0.01）,showing significant difference from those in healthy controls （P〈0.01）.In recovery stage,the levels of IL-6 and IL-17 of HFMD were significantly lower than those in acute stage,and also no significant difference showed from those in general children and in healthy controls （P〉0.05）.Conclusion The levels of IL-6 and IL-17 were significantly increased in acute stage of HFMD children.The persistent elevation of serum IL-10 and IL-13 levels were found in HFMD patients after convalescence.