阿托伐他汀钙预防高危患者急性脑梗死复发的前瞻性研究

目的:探讨阿托伐他汀钙预防高危患者急性脑梗死复发的临床药理疗效,观察阿托伐他汀钙对脑梗死患者血脂、血清炎性因子及颈动脉粥样硬化的影响,以指导临床用药。方法:156例首发急性脑梗死患者分为两组:对照组(n=66)给予常规治疗,观察组(n=90)加服阿托伐他汀钙20mg/d,疗程6个月。全部患者治疗前、治疗后6个月均测定血脂、炎性因子水平及颈动脉粥样硬化情况。结果:治疗6个月后观察组血脂、血清炎性因子水平及IMT、颈动脉斑块面积明显优于对照组(P<0.05或0.01);观察组6个月脑梗死复发率显著低于对照组(5.56%vs.21.2%,P<0.01)。结论:阿托伐他汀钙能够显著改善脑梗死患者血脂、血清炎性因子水平,稳定颈动脉粥样硬化斑块,促进斑块逆转,降低脑梗死复发风险。

Prospective study on Atorvastatin for prevention relapsed acute cerebral infarction in high-risk patient

Objective:To explore the clinical pharmacological effects of atorvastatin on preventing relapsed cerebral infarction in high-risk patient,and to investigate the influence of atorvastatin on the inflammatory factors,serum lipids and carotid artery atherosclerosis in patients with cerebral infarction.Methods:A total of 156 patients with the first onset of acute cerebral infarction were divided into control group(n=66) and observation group(n=90).The control group was given conventional therapy,observation group take atorvastatin 20 mg/d,both for 6 months.Serum lipids and inflammatory factors,the carotid artery intimal and media thickness(IMT) and plaque areas were measured before and 6 months after treatment.Results:The improvement in serum lipids,carotid artery atherosclerosis,IMT and carotid artery plaque area in observation group were better than those in the control group(P<0.05 or 0.01).The six-month recurrence rate of observation group was significantly lower than that of the control group(5.56% vs.21.2%,P<0.01).Conclusion:Atorvastatin calcium can significantly improve endothelial function,lipid levels and carotid atherosclerotic plaque stability in patients with acute cerebral infarction,and promote plaque regression,reduced the recurrence rate of cerebral infarction.