| 硒蛋氨酸对食管癌放射抗拒细胞药物耐受性的影响 |
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| 引用本文： | 王艳,邓卫平,杨公利,陈滋华,童强,李胜保.硒蛋氨酸对食管癌放射抗拒细胞药物耐受性的影响[J].海南医学院学报,2013,19(5):630-632. |
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| 作者姓名： | 王艳 邓卫平 杨公利 陈滋华 童强 李胜保 |
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| 作者单位： | 湖北医药学院附属太和医院消化内科,湖北十堰,442000 |
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| 摘 要： | 目的:研究硒蛋氨酸对食管癌放射抗拒细胞药物耐受性的影响。方法:以食管癌EC9706细胞为研究对象,建立放射抗拒的食管癌EC9706细胞株EC9706R,研究硒蛋氨酸对EC9706R细胞的影响。结果:EC9706R细胞耐药指数是EC9706细胞的1.24倍,硒蛋氨酸浓度大于4μmol/L时明显降低EC9706R细胞对顺铂的药物耐受性(P<0.05)。结论:硒蛋氨酸对食管癌放射抗拒细胞的药物耐受性具有一定的逆转作用。
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| 关 键 词： | 食管癌细胞 放射抗拒 硒蛋氨酸 |
Effect of selenomethionine on drug-resistance of human esophageal radioresistance carcinoma cells |
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| Abstract: | Objective:To investigate the effect of selenomethionine on the drug-resistance of human esophageal carcinoma radioresistance cells.Methods:Radioresistant cells(EC9706R) were established by means of continuous fractionated gamma-ray irradiation upon human esophageal squamous cancer cell line EC9706.MTT assay was used to detect the effect of Selenomethionine on the drug-resistance of EC9706R.Results:The esophageal cancer radioresistant cells(EC9706R) showed increased cisplatin-resistance.4 μmol/Lselenomethionine had significantly effect on the cisplatin-resistance of EC9706R(P<0.05).Conclusions:Selenomethionine can overcome drug-resistance of esophageal squamous cancer radioresistant cellsn. |
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| Keywords: | Esophageal carcinoma cell Radioresistance Selenomethionine |
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