| 小G蛋白Rho与肾间质纤维化 |
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| 引用本文： | 王洪涛,周建华.小G蛋白Rho与肾间质纤维化[J].国外医学：内科学分册,2009,36(7):410-412,416. |
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| 作者姓名： | 王洪涛 周建华 |
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| 作者单位： | 王洪涛(湖北职业技术学院医学院,湖北,孝感,432000);周建华(华中科技大学同济医学院附属同济医院儿科,湖北,武汉,430030) |
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| 摘 要： | 肾间质纤维化是所有慢性进行性肾脏疾病进展到终末期肾衰竭的共同形态学特点。Rho蛋白作为重要的细胞内信号分子，调节细胞的多种行为和功能，包括细胞生长，细胞骨架的重组，细胞移行和增殖等。近年研究发现，Rho蛋白及相关信号通路在肾间质纤维化过程中起着重要作用。通过作用于该通路从而达到治疗或逆转肾功能进行性损害的目的，可成为一个新的研究方向。
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| 关 键 词： | 肾 纤维化 小G蛋白 Rho |
The small GTPase Rho and renal interstitial fibrosis |
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| WANG Hong-tao,ZHOU Jian-hua. Medical College of Hubei Polytechnic Institute,Xiaogan ,China.The small GTPase Rho and renal interstitial fibrosis[J].Foreign Medical Sciences(Section of Internal Medicine),2009,36(7):410-412,416. |
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| Authors: | WANG Hong-tao ZHOU Jian-hua Medical College of Hubei Polytechnic Institute Xiaogan China |
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| Institution: | WANG Hong-tao1,ZHOU Jian-hua2.1 Medical College of Hubei Polytechnic Institute,Xiaogan 432000,China,2 Department of Pediatrics,Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | Renal interstitial fibrosis is a final common pathway to the eventual structural desolation of kidneys.The small GTPase Rho participates in a wide variety of cell signal functions such as cell growth,cytoskeleton rearrangement,cell migration and proliferation.This review focused on the current understanding of the small GTPase Rho in renal interstitial fibrosis,and it may be an important therapeutic target to cure or reverse the progressive functional deterioration. |
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| Keywords: | Rho |
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