| 水飞蓟宾对小鼠腹腔巨噬细胞释放纤维化因子的影响 |
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| 引用本文： | 庄东平,王硕丰,章越凡,桂敏,张珉,张俊平. 水飞蓟宾对小鼠腹腔巨噬细胞释放纤维化因子的影响[J]. 药学实践杂志, 2006, 24(1): 20-22 |
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| 作者姓名： | 庄东平 王硕丰 章越凡 桂敏 张珉 张俊平 |
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| 作者单位： | 福建省惠安县人民医院药剂科,福建惠安362100;第二军医大学药学院药理学教研室,上海200433;第二军医大学药学院药理学教研室,上海200433;第二军医大学药学院药理学教研室,上海200433;第二军医大学药学院药理学教研室,上海200433;第二军医大学药学院药理学教研室,上海200433 |
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| 基金项目： | 国家自然科学基金资助项目(No.0171087). |
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| 摘 要： | 目的:研究水飞蓟宾对小鼠腹腔巨噬细胞释放纤维化因子的影响。方法:小鼠腹腔巨噬细胞先后用卡西霉素和脂多糖刺激培养24h诱导纤维化因子。巨噬细胞培养上清中促胶原合成活性和转化生长因子β活性分别采用3H-脯氨酸掺入法和雕肺上皮Mv-1-Lu细胞测定。结果:水飞蓟宾(6.25-50μg／mL)以浓度依赖方式抑制巨噬细胞产生胶原刺激活性和转化生长因子β1。结论:水飞蓟宾减少巨噬细胞释放促纤维化因子可能是其保肝抗硬化机制之一。
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| 关 键 词： | 水飞蓟宾 巨噬细胞 转化生长因子 纤维化 |
| 收稿时间： | 2005-09-05 |
Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages |
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| ZHUANG Dong-ping,Wang Shuo-feng,ZHANG Yue-fan,GUI Min,ZHANG Min and ZHANG Jun-ping. Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages[J]. The Journal of Pharmaceutical Practice, 2006, 24(1): 20-22 |
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| Authors: | ZHUANG Dong-ping Wang Shuo-feng ZHANG Yue-fan GUI Min ZHANG Min ZHANG Jun-ping |
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| Affiliation: | Department of Pharmacy, Huian People Hospital, Huian 362100, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | |
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| Keywords: | silybin macrophages transforming growth factor fibrosis |
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