Correlation among plasma osteocalcin,growth hormone,and somatomedin C in acromegaly |
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| Authors: | C. de la Piedra E. Carbó J. Larrañaga N. Castro C. Horcajada A. Rapado J. L. Herrera Pombo |
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| Affiliation: | (1) Unidad, Endocrinología, Fundación Jimenez Díaz, Centro Asociado al Consejo Superior de Investigaciones Científicas, Universidad Autónoma, Madrid, Spain;(2) Unidad Metabolismo, Nutricion y Hormonas, Fundación Jimenez Díaz, Centro Asociado al Consejo Superior de Investigaciones Científicas, Universidad Autónoma, Madrid, Spain;(3) Fundación Jimenez Díaz, Unidad Metabolica, Avda Reyes Católicos 2, 28040 Madrid, Spain |
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| Abstract: | Summary Plasma osteocalcin (BGP), growth hormone (GH), and somatomedin C(SmC) were measured in 12 patients with acromegaly [7 clinically active (aA), 5 cured (cA)] and 9 control subjects (C). Basal plasma values for the three parameters were higher in aA than in C and in cA. No significant difference was found between cA and C. A significant linear correlation between BGP and GH and between BGP and SmC was obtained. These results suggest an effect of GH on BGP synthesis, possibly mediated by SmC, although a direct effect of GH on bone cannot be exclulded. |
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| Keywords: | Osteocalcin Growth hormone Somatomedin C Acromegaly |
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