高渗溶液对高原烧伤犬休克复苏时血流动力学的影响

目的：探讨高原条件下，烧伤休克复苏的方法。方法：模拟４０００ｍ高原条件下，利用犬４０％ＴＢＳＡⅢ度烫伤模型，２４只犬被随机分为平原等渗组、平原高渗组、高原等渗组和高原高渗组，伤手１ｈ开始补液。观察伤前、伤后２、６、１２、２４ｈ和４８ｈ股动脉血压（ＦＡＰ）、肺动脉血压（ＰＡＰ）、肺动脉楔状压（ＰＡＷＰ０、肺血管阻力（ＰＶＲ）、中心静脉压（ＣＶＰ０、心输出量（ＣＯ）和心排指数（ＣＩ）等血流动力学参数及

Effects of hypertonic solution on hemodynamic parameters during burn shock resuscitation under high altitude in dogs

Objective: To evaluate the resuscitationaltechniques for burn shock under high altitude condition. Methods: 24 dogsw ere inflicted with 40% TBSA fullthickness scalding and random ized equally into norm al altitude isotonic fluid infusion (NI) group, norm alaltitude hypertonic fluid infusion (NH) group, high altitude (sim ulated 4 000 m ) isotonic fluid infusion (HI) group and high altitude hypertonicfluid infusion (HH)group. Fluid infusion began 1h postburn.Fem oralarterialpressure(FAP), pulmonary arterial pressure (PAR), pulm onary arterial wedge pressure (PAWP), pulm onary vascular resistance (PVR), centralvenous pressure(CVP), cardiacoutput(CO) and cardiacindex (CI) w ere measured in the 2nd, 6th, 12th, 24th and 48th hour postburn. Results: PAPand PVRwere significantly higherin the HI and HHgroupsthan in the NIand NH groups. PAP, PAWP, PVRand w atercontentoflung tissues were significant higher in the HIgroup than in the HH group but FAP, CO and CIshowed no significant difference between NIand NHgroups.Conclusion:When burn shock istreated in high altituderegions,the adm inistration ofhypertonic solution is ableto abatethe developm entofpulm onary edem a.