Erythrocyte indexes, iron metabolism, and hyperhomocysteinemia in adults with cyanotic congenital cardiac disease |
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Authors: | Kaemmerer Harald Fratz Sohrab Braun Siegfried L Koelling Klaus Eicken Andreas Brodherr-Heberlein Silke Pietrzik Klaus Hess John |
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Institution: | Klinik für Kinderkardiologie und angeborene Herzfehler, Lazarettstrasse 36, 80636 Munich, Germany. Kaemmerer@dhm.mhn.de |
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Abstract: | A high percentage of cyanotic adults (37%) with cyanotic congenital cardiac disease (CCD) presented with depleted iron stores (13 of 52) or latent iron deficiency (6 of 52), even in a CCD center in which cyanotic patient phlebotomy is mostly avoided. In many of these patients, hypochromia and microcytosis was frequent, whereas hyperchromia and macrocytosis were relatively common.Furthermore, 50% of patients presented with hyperhomocysteinemia, possibly related to folate or B vitamin deficiencies, which may increase red blood cell size and color, explaining the lack of microcytosis and hypochromia in many cyanotic patients with iron deficiency. |
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