| 期望频数较小时Hardy-Weinberg平衡检验的确切概率计算 |
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| 引用本文： | 苏炳华,李哲先,张建良,陈婉苏,史秉璋,陈仁彪.期望频数较小时Hardy-Weinberg平衡检验的确切概率计算[J].上海交通大学学报(医学版),1989(2). |
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| 作者姓名： | 苏炳华 李哲先 张建良 陈婉苏 史秉璋 陈仁彪 |
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| 作者单位： | 上海第二医科大学生物医学工程系生物统计教研室
(苏炳华，张建良，陈婉苏，史秉璋)，北京友谊医院
(李哲先)，上海第二医科大学基础部医学遗传教研室(陈仁彪) |
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| 摘 要： | Hardy-Weinberg平衡是群体遗传学的基本规律。当在等位基因数较多作该平衡的吻合度检验时,特别是HLA分型分析中常遇到理论频数较小的情况下,本文作者设计了一种确切概率计算法,确切地处理了该问题。
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| 关 键 词： | Hardy-Weinberg平衡 确切概率 X~2检验 |
Calculation of Exact Probability for Hardy-Weinberg Equilibrium Test with Small Samples |
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| Su Binhua,et al.Calculation of Exact Probability for Hardy-Weinberg Equilibrium Test with Small Samples[J].Journal of Shanghai Jiaotong University:Medical Science,1989(2). |
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| Authors: | Su Binhua |
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| Institution: | Su Binhua,et al Department of Biostatisties,Shanghai Second Medical University,Shanghai |
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| Abstract: | Hardy-Weinberg equilibrium is a basic principle in population genetics. in doing the test for goodness of fit of the equilibrim there are sometimes situations, particularly in HLA analysis, in which there are multiple alleles and the theoretical frequency for each term could be only a very small number. Reported in this paper is a method to calculate the exact probability for Hardy-Weinberg equilibrium test with small samples. |
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| Keywords: | Hardy-Weinberg equilibrium Exact probability X~2 test |
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