HLA antigens in Arab children with steroid-responsive nephrotic syndrome |
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| Authors: | Moh'd Zaki Azhar S. Daoud Qusay A. Al Saleh A. Khuder Al Najedi Arthur G. White |
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| Affiliation: | (1) Department of Paediatrics, Farwania Hospital, Kuwait;(2) Department of Organ Transplantation, Faculty of Medicine, Kuwait University, Kuwait;(3) Present address: Department of Surgery, College of Medicine, Sultan Qaboos University, Sultanate of Oman;(4) PO. Box 25850, I3119 Safat, Kuwait |
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| Abstract: | Forty-eight Arab patients with steroid-responsive childhood nephrotic syndrome were studied for the frequency of HLA-A,-B,-C and-DR antigens. HLA-DR7 was significantly increased in the patient group (63% vs. 28%,P=0.0002) confirming reports of a DR7 association in other ethnic groups and indicating a universal association with this antigen. HLA-CW6 was also significantly increased (44% vs. 21%,P corr.=0.042). HLA-DQW1 was significantly reduced in the patients (29% vs. 57%,P corr.=0.012) as was HLA-CW4 (6% vs. 24%,P corr.=0.042). |
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| Keywords: | HLA Arabs Nephrotic syndrome |
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