| 生脉注射液HPLC指纹图谱的建立 |
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| 引用本文： | 郑笑为,汪祺,于建东,刘燕,戴忠,鲁静,林瑞超.生脉注射液HPLC指纹图谱的建立[J].药物分析杂志,2012(8):1471-1475. |
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| 作者姓名： | 郑笑为 汪祺 于建东 刘燕 戴忠 鲁静 林瑞超 |
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| 作者单位： | 中国食品药品检定研究院 |
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| 摘 要： | 目的:建立生脉注射液的HPLC指纹图谱。方法:采用Waters Symmetry ShieldTMRP18(4.6 mm×250 mm,5μm)色谱柱,以乙腈-水为流动相,梯度洗脱,流速为1 mL.min-1,检测波长203 nm,柱温30℃。结果:本色谱条件下生脉注射液各成分得到了良好分离,指纹图谱由23个特征峰组成。结论:所建立的指纹图谱分离效果好,信息量大,可作为生脉注射液的指纹图谱使用,以便更好地控制该产品的质量。
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| 关 键 词： | 生脉注射液 特征成分指纹图谱 高效液相色谱 中药注射剂质量控制 人参皂苷 五味子原人参三醇 五味子甲素 五味子乙素 五味子醇甲 五味子酯甲 |
Establishment of HPLC fingerprint of Shengmai injection |
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| ZHENG Xiao-wei,WANG Qi,YU Jian-dong,LIU Yan,DAI Zhong,LU Jing,LIN Rui-chao.Establishment of HPLC fingerprint of Shengmai injection[J].Chinese Journal of Pharmaceutical Analysis,2012(8):1471-1475. |
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| Authors: | ZHENG Xiao-wei WANG Qi YU Jian-dong LIU Yan DAI Zhong LU Jing LIN Rui-chao |
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| Institution: | (National Institutes for Food And Drug Control,Beijing 100050,China) |
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| Abstract: | Objective:To establish HPLC fingerprint of Shengmai injection.Methods:A Waters Symmetry ShieldTM RP18(4.6 mm×250 mm,5 μm)was adopted,acetonitrile-water(gradient elution) system was used as a mobile phase at flow rate of 1 mL·min-1,the detection wavelength was 203 nm,and colum temperature was set at 30 ℃.Results:According to the selected chromatographic conditions,standard fingerprint consisting of 23 communal peaks was obtained.Conclusion:The fingerprint established has the good separate effect and includes a lot message.It should be used as fingerprint,so that the quality of Shengmai injection can be controlled better. |
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| Keywords: | Shengmai injection character compound fingerprint HPLC CTM injection quality control ginsenoside Fructus Schisandrae Chinensis protopanaxatriol deoxyschizandrin schisandrin B schisandrin Wuweizi ester A |
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