甲氨碟呤联用卡介苗多糖核酸治疗激素依赖型哮喘的临床研究

目的研究甲氨喋呤(MTX)联用卡介苗多糖核酸(BCG-PSN)治疗激素依赖型哮喘的疗效和安全性。方法将68例激素依赖型哮喘随机分为治疗组和对照组,治疗组给予MTX、BChG-PSN;对照组单用MTX,治疗期均为3个月。记录试验前、后患者的临床症状评分、PEF、FEV1、强的松每日用量。检测药物不良反应。结果两组临床症状评分、强的松日用量均较治疗前有显著减少(P<0.05),治疗组的减少更为明显,且与对照组相比,差异具有显著性(P<0.05);治疗组治疗后PEF、FEV1较治疗前明显增加(P<0.05),对照组治疗后PEF、FEV1无显著性改变(P>0.05);两组治疗过程中均未发现严重的不良反应,不良反应发生率两组无差别(P>0.05),但对照组有2例患者发生呼吸道感染。结论MTX联用BCG-PSN治疗激素依赖型哮喘疗效可靠,不良反应少,优于单用MTX,是一种安全有效的治疗方案。

Clinical study of methotrexate and Bacille Calmette Guerin-polysaccharide nucleic acid in the treatment of steroid dependent asthma

Objective To investigate the efficacy and adverse effects of methotrexate(MTX) and Bacille Calmette Guerin-polysaccharide nucleic acid(BCG-PSN) in the treatment of steroid dependent asthma.Methods Sixty-eight patients with steroid dependent asthma were divided into therapy group and control group.The patients in therapy group were treated with MTX and BCG-PSN,while the control group was given only MTX.The dose of oral steroid daily,symptom scores,peak flow rates(PEF) and expiratory volume in one second(FEV1) were monitored.Results Compared with before treatment,daily steroid dosage and symptom scores of two groups significantly decreased(P<0.05).The decrease in therapy group was more significant than that in control group(P<0.05).There was no difference on PEF and FEV1 in control group between before and after the treatment(P>0.05),while PEF and FEV1 significantly increased in therapy group(P<0.05).The two groups had no significant difference in adverse events(P>0.05).Conclusion The combined use of MTX and BCG-PSN may be more beneficial than the single use of MTX for the treatment of steroid-dependent asthma.