丹参治疗急性一氧化碳中毒病人心肌损伤的研究

目的探讨丹参对中重度急性一氧化碳中毒(ACOP)病人心肌损伤的治疗作用.方法 28例随机分为丹参治疗组14例和对照组14例,检测接诊后0 h、8 h、1 d、3 d、7 d及10 d时血清心肌肌钙蛋白I(cTnI)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)及心电图并进行比较.结果治疗组血清cTnI水平在接诊后1 d、7 d及10 d时显著低于对照组(P<0.01～P<0.05),CK及CK-MB在接诊后3 d及7 d时显著降低(P<0.05),而在10 d时此3项指标在两组间比较无统计学意义(P>0.05).治疗组心律异常/ST-T异常天数亦显著低于对照组(P<0.05).结论丹参能有效减轻急性一氧化碳中毒病人心肌损伤的程度,减少心电图异常的发生,但并不能缩短心肌损伤的病程.

The Effect of Salvia Miltiorrhiza on Myocardial Damage in Acute Carbon Monoxide Poisoning

Objective To study the effect of salvia miltiorrhiza on myocardial damage in moderate and severe acute carbon monoxide poisoning (ACMP).Methods Twenty-eight patients (pts) with moderate and severe ACMP were divided into salvia miltiorrhiza group (Group S) and control group(Group C).Serum troponin I(cTnI),creatine kinase(CK),MB isoenzyme of CK(CK-MB)and electrocardiogram were analyzed at 0 h, 8 h, 1 d, 3 d, 7 d and 10d after the emergency acceptance.Results The serum cTnI levels in 1 d, 7 d and 10 d were lower significantly in Group S than that in Group C(P<0.01,P<0.01 and P<0.05,respectively),and CK and CK-MB levels were also lower in 3 d and 7 d (P<0.05),but in 10 d.The duration of arrhythmia / abnormal ST-T changes was shorter significantly in Group S than that in group C (P<0.05).Conclusion Salvia miltiorrhiza,applied for pts with ACMP,may be effectively to reduce the severity of myocardium damage and the electrocardiogram abnormality.The course of myocardium injury could not be shorten by it.