| Fas配体和细胞黏附分子1在肥大扁桃体组织高内皮小静脉中的表达及意义 |
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| 引用本文： | 刘阳,王志斌,余海静,王芳,刘胜洪,崔永华.Fas配体和细胞黏附分子1在肥大扁桃体组织高内皮小静脉中的表达及意义[J].临床耳鼻咽喉头颈外科杂志,2007,21(15):700-702. |
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| 作者姓名： | 刘阳 王志斌 余海静 王芳 刘胜洪 崔永华 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院耳鼻咽喉-头颈外科,武汉,430030;华中科技大学同济医学院附属同济医院感染科;华中科技大学同济医学院胚胎学教研室 |
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| 基金项目： | 湖北省卫生厅科研基金项目（No：JXIB043） |
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| 摘 要： | 目的：探讨Fas配体（FasL）和细胞黏附分子1（ICAM-1）在肥大扁桃体组织高内皮小静脉（HEV）中的表达及意义。方法：收集37例扁桃体切除标本,其中20例为慢性肥大性扁桃体炎患者（CHT组）,17例为特异性扁桃体肥大患者（ITH组）。应用苏木精-伊红染色法和免疫组织化学染色（SABC法）研究2组扁桃体组织HEV的T、B淋巴细胞的数目,内皮细胞中FasL及ICAM-1的表达。结果：CHT组HEV中ICAM-1的表达明显高于ITH组（P〈0.05）,而ITH组HEV中FasL的表达明显高于CHT组（P〈0.05）。结论：HEV内皮细胞表达的ICAM-1和FasL均可能在扁桃体肥大的发生、发展过程中起一定的促进作用,前者主要促进CHT发展,后者主要导致ITH。
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| 关 键 词： | 高内皮小静脉 Fas配体 细胞黏附分子1 扁桃体 |
| 文章编号： | 1001-1781（2007）15-0700-03 |
| 修稿时间： | 2006-11-29 |
The expression of FasL and ICAM-1 on the HEVs in the hypertrophic tonsils |
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| LIU Yang,WANG Zhibin,YU Haijing,WANG Fang,LIU Shenghong,CUI Yonghua.The expression of FasL and ICAM-1 on the HEVs in the hypertrophic tonsils[J].Journal of Clinical Otorhinolaryngology,2007,21(15):700-702. |
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| Authors: | LIU Yang WANG Zhibin YU Haijing WANG Fang LIU Shenghong CUI Yonghua |
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| Institution: | 1 Department of Otorhinolaryngology-Head and Neck Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;2 Department of Infectious Disease,Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology ; 3 Department of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology |
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| Abstract: | Objective:To investigate the expression of FasL and ICAM-1 on the HEVs in the hypertrophic tonsils and its clinical significance.Method:Under the light microscopy, HE and immunohistochemistry methods were used to show the morophology of HEVs, the number of T,B lymphocytes, the expression intensity of FasL and ICAM-1 in 17 patients with the idiopathic tonsillar hypertrophy(ITH) and in 20 patients with the chronic hypertrophic tonsillitis (CHT).Result:The expression intensity of ICAM-1 on the tonsillar HEVs in ITH group was significantly lower than that in CTH group( P <0.05), but the intensity of FasL in ITH group was significantly higher than that in CHT group( P <0.05).Conclusion:FasL and ICAM-1 expression in the tonsillar HEVs contribute to the CHT and ITH. The former mainly makes IHT develope, and the latter promotes the process of the inflammation. |
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| Keywords: | High endothelial venules FasL Intercellular adhesion molecule-1 Tonsils |
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