中老年女性血清25羟维生素D水平与骨密度、体质量指数的调查研究

目的调查深圳市中老年女性人群血清25羟维生素D水平、骨密度(bone mineral density,BMD)和体质量指数(body mass index,BMI)并探讨其相关性,为骨质疏松症(osteoporosis,OP)的防治提供相应的依据。方法收集2018年10月至2019年2月于深圳平乐骨伤科医院(坪山区中医院)参与调查的中老年女性212例[年龄50～84岁,平均(60. 1±7. 8)岁],测量受试者的身高、体重,计算BMI,根据BMI分成体重过低组(6例)、正常体重组(112例)和超重组(94例),分别测量各组骨密度和血清25羟维生素D水平。采用Spearman相关分析观察指标间的相关性。结果体重过低组、正常体重组和超重组三组的OP患病率依次为:83. 3%、58. 0%和57. 4%,三组的差异不具有统计学意义(P0. 05)。正常体重组的25羟维生素D与BMD、BMI均不存在相关关系(P0. 05),BMD与年龄的关系呈负相关,与身高、体重均呈正相关(P0. 05),但是与BMI之间则不存在相关性(P0. 05)。在超重组中,25羟维生素D与BMI呈负相关,BMD与年龄呈负相关,与身高呈正相关(P0. 05),但是与体重、BMI之间的相关性无统计学意义(P0. 05)。结论在BMI正常范围内,高体重是OP的保护因素,而超重时则不存在此关系。且超重对中老年女性的血清25羟维生素D水平可产生负面影响。过重的体重可能不利于OP的防治,中老年女性应控制体重在正常范围内。

A study on the relationship of serum 25-hydroxyvitamin D levels, bone mineral density and body mass index in middle-aged and elderly women

Objective To investigate serum 25-hydroxyvitamin D levels, bone mineral density (BMD) and body mass index (BMI) in middle-aged and elderly women in Shenzhen city and to explore their correlations, so that corresponding evidence can be provided for the prevention and treatment of osteoporosis (OP) . Methods A total of 212 middle-aged and elderly females (aged 50-84 years old, average 60.11±7.84 years) from Shenzhen city, participated in the survey in our hospital from October 2018 to February 2019. Their height and weight measured, BMI calculated, and were divided into three groups according to BMI: the underweight group (6 cases), the healthy weight group (112 cases), and the overweight group (94 cases). Then their BMD and serum 25-hydroxyvitamin D levels were examined separately. Spearman correlation was used to analyze the relative relationship between the indicators. Results The prevalence of OP among the three groups were 83.3%, 58.0% and 57.4%, respectively, and the difference among the groups was not statistically significant (P>0.05). In healthy weight group, there was no compelling correlation among 25-hydroxyvitamin D, BMD and BMI (P>0.05). BMD showed a negative correlation with age, a favorable correlation with height and weight (P<0.05), while no correlation with BMI (P> 0.05) in this group. In overweight group, 25-hydroxyvitamin D was negatively correlated with BMI. There existed negative correlation between BMD and age, and positive correlation between BMD and height (P<0.05). No significant correlation was observed among BMD, weight and BMI (P>0.05) in this group. Conclusion High body weight is a protective factor for OP in the normal range of BMI, while there is no correlation when overweight. Overweight can have a negative impact on serum 25-hydroxyvitamin D levels in middle-aged and elderly women. Excessive weight may not be conducive to the prevention and treatment of OP, and middle-aged and elderly women should control their body weight within the normal range.