Serum angiotensin converting enzyme activity in ex-smokers |
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| Affiliation: | 1. State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China;2. Respiratory Medicine department of Taihe Hospital, Hubei University of Medicine, Hubei, China;1. Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;2. Institute for Chemical Carcinogenesis and State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 511436, China |
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| Abstract: | A low activity of angiotensin converting enzyme (ACE) has been reported in people who smoke. To determine whether this low ACE activity would be reversible on cessation of smoking, we measured serum ACE activity in 107 healthy male volunteers. They included 27 active cigarette smokers, 28 non-smokers, 24 ex-smokers who had stopped smoking for less than 10 yr, and 28 ex-smokers who had stopped smoking for more than 10 yr. The mean value (±SD) of serum ACE in those who had stopped smoking for more than 10 yr was comparable to that of non-smokers: 23.2 ± 5.1 and 23.5 ± 4.5, respectively. ACE activity in smokers and the ex-smokers who had stopped smoking for less than 10 yr was significantly lower (17.8 ± 4.5 and 17.8 ± 3.9, respectively) than values obtained in non-smokers and the group who had not smoked for more than 10 yr (p < 0.001). These findings suggest that the effect of chronic smoking on the serum ACE activity may be reversible. |
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