面肌痉挛的电生理变化及用A型肉毒杆菌毒素治疗的临床研究

为探讨面肌痉挛的病因和病理，评估 A型肉毒杆菌毒素治疗面肌痉挛的疗效，对240例病人进行面部肌肉多点注射A型肉杆菌毒素治疗，对治疗前后的病情分级进行对比，并随机抽取68例行肌电图检查。结果显示，A型肉毒杆菌毒素有效率96％，半年复发率为80％。肌电图显示患乾面神经潜伏时延长，眼轮匝肌、口轮匝肌肌电图诱发运动电位振幅下降。提示A型肉毒杆菌毒素治疗面肌痉挛为一种简单有效的对症治疗方法。

ELECTROPHYSIOLOGIC CHANGES AND THE THERAPEUTIC EFFECTS OF BOTULIN A ON HEMIFACIAL SPASM

To explore the cause and pathology of hemifacial spasm and evaluate the therapeutic efficacy of butulin A, 240 HFS patients were studied for therapeutic efficacy of multifocal facial injections with botulin A. Symptomatic alleviations after the injection were graded in comparison with the symptoms in the pre-treatment stage. Electromyography (EMG) was performed in 68 patients at random. Following the treatment, 96% of the patients were relieved of symptomes, but in 80% of the patients the symptom relapsed about one half a year later. The results showed that the latent period of EMG was longer than normal facial muscle, and the amplitude of evoked movement potential of EMG of orbiticularis occuli muscle and orbiticularis oris muscle was decreased. The cause of hemifacial spasm was resulted from pathological stimulation of the facial nerve, producing abnormal nervous conduction. The therapeutic hemifacial spasm with botulin A is an easy and effective method.