| 女性生殖道鳞状上皮病变的HPV原位杂交检测 |
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| 引用本文： | 郭东辉,庞淑洁.女性生殖道鳞状上皮病变的HPV原位杂交检测[J].诊断病理学杂志,2005,12(4):289-291,i0013. |
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| 作者姓名： | 郭东辉 庞淑洁 |
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| 作者单位： | 天津市中心妇产科医院,病理科,天津,300052 |
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| 摘 要： | 目的观察女性生殖道鳞状上皮病变的HPV表达与意义。方法应用原位杂交技术对186例女性生殖道鳞状上皮病变组织进行HPV611、HPV1618和HPV3133定型检测。结果尖锐湿疣HPV611的阳性表达占96.4%,宫颈上皮内瘤变1级(CIN1)中HPV611与HPV1618阳性表达分别为47.6%和50%,HPV检测多项阳性病例占17.1%。结论CIN1中存在高危型HPV感染病例,混合性HPV感染在CIN中不少见。
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| 关 键 词： | 鳞状上皮病变 HPV 原位杂交 |
| 文章编号： | 1007-8096（2005）04-0289-03 |
| 收稿时间： | 2004-09-28 |
| 修稿时间： | 2004-09-28 |
Detection of HPV by in situ hybridization in squamous cell lesions of female genital tract |
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| GUO Dong-hui,PANG Shu-jie.Detection of HPV by in situ hybridization in squamous cell lesions of female genital tract[J].Chinese Journal of Diagnostic Pathology,2005,12(4):289-291,i0013. |
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| Authors: | GUO Dong-hui PANG Shu-jie |
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| Abstract: | Objective To observe HPV expression and its significance in squamous cell lesions of female genital tract. Methods HPV6/11, HPV16/18 and HPV31/33 were detected by in situ hybridization techniques in 186 cases of squamous cell lesions of female genital tract. Results The positive expression of the HPV6/11 in the condyloma was 96^4%. Of the CIN1, 47^6% were positive for HPV6/11 and 50% were positive for HPV16/18 respectively. Two or more types of HPV were found in 17^1% of the cases. Conclusion Some cases with high_risk HPV infection exist in CIN1, and cases of HPV infections with more than one type is not rare. |
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| Keywords: | Squamous cell lesions HPV In situ hybridization |
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