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Anti-inflammatory Effects of Novel P2X4 Receptor Antagonists,NC-2600 and NP-1815-PX,in a Murine Model of Colitis |
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| Authors: | D’Antongiovanni Vanessa Pellegrini Carolina Benvenuti Laura Fornai Matteo Di Salvo Clelia Natale Gianfranco Ryskalin Larisa Bertani Lorenzo Lucarini Elena Di Cesare Mannelli Lorenzo Ghelardini Carla Nemeth Zoltan H. Haskó György Antonioli Luca |
| Affiliation: | 1.Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy ;2.Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy ;3.Department of Neuroscience, Psychology, Drug Research and Child Health, Neurofarba, Pharmacology and Toxicology Section, University of Florence, Florence, Italy ;4.Department of Surgery, Morristown Medical Center, Morristown, NJ, 07960, USA ;5.Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, 10032, USA ;6.Unit of Pharmacology and Pharmacovigilance, Department of Clinical and Experimental Medicine, University of Pisa Via Roma 55, 56126 Pisa, Italy ; |
| Abstract: | Inflammation - The pharmacological blockade of P2X4 receptors has shown potential benefits in the management of several immune/inflammatory diseases. However, data regarding the involvement of P2X4... |
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