冠状动脉介入治疗造影剂肾病危险因素及发病机制研究进展

冠心病介入治疗术后造影剂肾病的发病机制十分复杂。与造影剂的直接细胞毒性效应、肾髓质缺血性损伤、氧自由基损伤及血管活性物质失衡、造影剂造成的细胞凋亡,免疫损伤及肾小管梗阻等因素有关。发病危险因素更涉及基础肾功能受损、糖尿病、造影剂的剂量和理化性质、脱水、慢性心力衰竭、高血压、高龄（〉70岁）、肝功能异常、低血钾、周围血管病变、使用肾毒性药物（如非甾体消炎药）及多发性骨髓瘤等。现就造影剂肾病的发病机制和相关危险因素的研究现状进行综述。

Advancement of Contrast-induced Nephropathy and Hydration Treatment after Percutaneous Coronary Intervention

The pathogenesis of contrast nephropathy is very complex after percutaneous coronary intervention.It is related the direct cytotoxic effects,ischemic injury of Kidney medulla,oxygen free radical damage and vascular active substances imbalance,the cell apoptosis,immune injury and renal tubular obstruction caused by contrast agents.The risk factors consist of chronic renal dysfunction-diabetes,diabetes,the dose and physical and chemical properties of contrast agent,dehydration,Chronic heart failure,hypertensi...