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One Step Nucleic Acid Amplification (OSNA) - a new method for lymph node staging in colorectal carcinomas |
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| Authors: | Roland S Croner Vera Schellerer Helene Demund Claus Schildberg Thomas Papadopulos Elisabeth Naschberger Michael Stürzl Klaus E Matzel Werner Hohenberger Anne Schlabrakowski |
| Affiliation: | (1) Department of Surgery, University of Erlangen-Nuremberg, Germany;(2) Department of Pathology, Vivantes Humboldt-Clinic, Berlin, Germany;(3) Department of Molecular and Experimental Surgery, University of Erlangen-Nuremberg, Germany;(4) Department of Pathology, University of Erlangen-Nuremberg, Germany |
| Abstract: | BackgroundAccurate histopathological evaluation of resected lymph nodes (LN) is essential for the reliable staging of colorectal carcinomas (CRC). With conventional sectioning and staining techniques usually only parts of the LN are examined which might lead to incorrect tumor staging. A molecular method called OSNA (One Step Nucleic Acid Amplification) may be suitable to determine the metastatic status of the complete LN and therefore improve staging. |
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