Comparative study of cardioprotective and antiradical activity of estrogens and their nitro derivatives |
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| Authors: | A I Matyushin V Yu Balaban'yan V M Rzheznikov A Zh Mambetova |
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| Institution: | (1) Department of Molecular Pharmacology and Radiobiology, Medico-Biological Faculty, Russian State Medical University, Moscow |
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| Abstract: | Cardioprotective and antiradical activities of estrogens and their nitro derivatives are compared. Antiradical activity was
observed in estradiol, ethanol estradiol, and estradiol nitrate, but not in nystranol, which exhibited antiradical properties
only after acid hydrolysis. The data obtained on hearts from rats with experimental myocardial infarction show that estrogens
and their nitro derivatives restrict the area of myocardial infarction due to antiischemic and/or antinecrotic activities.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 10, pp. 408–410, October, 1999 |
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| Keywords: | antiradical activity nitro estrogens experimental myocardial infarction |
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