Increased CSF amino acids and ventricular enlargement in schizophrenia: a preliminary study |
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| Authors: | M A Reveley J De Belleroche A Recordati S R Hirsch |
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| Affiliation: | 1. Lentis Psychiatric Institute, Lentis Research, Groningen, the Netherlands;2. University of Groningen, University Medical Center Groningen, Rob Giel Research Center, Groningen, the Netherlands;3. University of Groningen, Faculty of Behavioural and Social Sciences, Groningen, the Netherlands;4. University of Groningen, Faculty of Economics and Business, Groningen, the Netherlands;5. Maastricht University, Faculty of Psychiatry & Psychology, Maastricht, the Netherlands;6. Mondriaan Mental Health Trust, Heerlen-Maastricht, the Netherlands;1. Department of Psychiatry, Valdecilla Biomedical Research Institute (HUMV-IDIVAL), Santander, Spain;2. Biomedical Research Networking Center for Mental Health (CIBERSAM), Madrid, Spain;3. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, ISCIII, Madrid, Spain;4. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, 161 Barry Street, Carlton South, Victoria, Australia |
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| Abstract: | We found significantly higher levels of cerebrospinal fluid alanine, glycine, leucine, and phenylalanine in schizophrenic patients compared to healthy controls. Ventricular enlargement was present in 4 of 11 schizophrenics, and elevated CSF alanine was highly correlated with ventricular enlargement. The implications of these findings are discussed. |
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