高压氧对高血压脑出血患者血浆ET、CGRP的影响

目的探讨高压氧对高血压脑出血患者血浆内皮素(ET)、降钙素基因相关肽(CGRP)的影响。方法选择70例高血压脑出血患者,随机分为高压氧治疗组和常规治疗组,每组35例;2组均予常规治疗,高压氧治疗组在常规治疗的基础上于入院后第5天生命体征稳定后进行高压氧治疗,每天1次,共治疗14 d。采用放射免疫法在治疗不同时间点(24 h、5 d、14 d、21 d)分别测血浆ET、CGRP值。另选择35例健康体检者作为正常对照组。结果入院时24 h高压氧治疗组及常规治疗组ET值高于正常对照组,CGRP值低于正常对照组。入院后(14 d、21 d)高压氧治疗组ET值低于常规治疗组,CGRP值高于常规治疗组。结论高压氧治疗可以降低血浆ET水平,提高CGRP含量,从而改善高血压脑出血患者预后,并对继发性脑损伤有一定的治疗作用。

Effect of hyperbaric oxygenation on plasma endothelin and calcitonin-gene-related peptide in hypertensive cerebral hemorrhage patients

Objective It is to investigate the effect of hyperbaric oxygenation on plasma endothelin(ET) and calcitonin gene-related peptide(CGRP).Methods 70 hypertensive cerebral hemorrhage patients were randomly divided into hyperbaric oxygenation therapeutic group and conventional therapy group(35 cases in each group).Beside the conventional therap,patients in hyperbaric oxygenation therapeutic group also received hyperbaric oxygenation in the fifth day after being in hospital if the body signs were stable,once a day and for 14 days.The developments of ET and CGRP levels in serum from both groups were monitored(24 h,5 d,14 d,21 d) with radioimmunoassay,35 healthy people(control group) were enrolled in this study.Results The level of ET was higher and the level of CGRP was lower in treatment group and conventional therapy group than that in normal control group in 24 h after being in hospital.The level of ET was lower and the level of CGRP was higher in hyperbaric oxygenation therapy group after therapy at 14 d and 21 d than that in conventional therapy(P<0.05).Conclusion Hyperbaric oxygenation can decrease plasma endothelin and increase calcitonin gene-related peptide,thus to protect secondary brain injury partially and improve prognosis of hypertensive cerebral hemorrhage patients.