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| 白藜芦醇对胎鼠发育影响的研究 | |
| 引用本文： | 许洁,俞捷,汪洋,龚磊,李岩,胡斌丽. 白藜芦醇对胎鼠发育影响的研究[J]. 中国妇幼保健, 2011, 26(14): 2185-2186 |
| 作者姓名： | 许洁 俞捷 汪洋 龚磊 李岩 胡斌丽 |
| 作者单位： | 1. 遵义医学院预防教研室,贵州,遵义,563003 2. 重庆医科大学公共卫生学院 3. 遵义医学院附属医院药剂科 |
| 摘 要： | 目的:探讨孕期接触植物雌激素白藜芦醇(resveratrol,RES)对大鼠胚胎发育的影响。方法:SD大鼠(每组8只)妊娠第9～15天灌胃RES,分为对照组(蒸馏水),RES不同剂量(5、15、45 mg/kg)组。于妊娠第20天测量胎鼠身长、尾长和胎盘、脏器重量,统计每窝平均胎数、活胎数、死胎数及吸收胎数,称重胎鼠的脑、睾丸、肝脏、心脏,测定孕鼠胎盘组织中超氧化物歧化酶(SOD)活力及脂质过氧化产物丙二醛(MDA)含量进行比较。结果:与对照组比较,RES各剂量组胎鼠各生理发育指标及胎盘组织中SOD活力、MDA含量差异均无统计学意义(P>30.05)。结论:该实验设计的剂量范围下,RES的雌激素样作用对胎鼠的发育无不良影响,孕期食用白藜芦醇及其制剂是相对安全的。 |
| 关 键 词： | 白藜芦醇 胚胎 发育 |
The effect of RES on embryonic development in rat |
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| XU Jie,YU JIE,WANG Yang,et al.. The effect of RES on embryonic development in rat[J]. Maternal and Child Health Care of China, 2011, 26(14): 2185-2186 | |
| Authors: | XU Jie YU JIE WANG Yang et al. |
| Affiliation: | XU Jie,YU JIE,WANG Yang,et al.Department of Preventive Medicine,Zunyi Medical College,Guizhou 563003,Guizhou,China |
| Abstract: | Objective:To explore the influence of Resveratrol(RES) on the growth and development of fetal rats.Methods:On gestational days(GD) 9-15,SD rats were orally administered with RES at doses of 5,15 and 45 mg/kg and distilled water for control,respectively.On gestational days(GD) 20,the body and tail lengths,the weights of placenta and organs of embryonic rats were measured;The number of live pups per litter,mean litter size,average numbers of death embryos and absorption embryos were calculated;The weights of ... |
| Keywords: | Resveratrol Embryo Development |
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