| 三磷酸腺苷-氯化镁对新生大鼠高氧肺损伤的影响 |
| |
| 引用本文： | 尹永日,金正勇,金美花.三磷酸腺苷-氯化镁对新生大鼠高氧肺损伤的影响[J].中国妇幼保健,2011,26(12):1870-1872. |
| |
| 作者姓名： | 尹永日 金正勇 金美花 |
| |
| 作者单位： | 延边大学附属医院儿科,吉林,延吉,133000 |
| |
| 摘 要： | 目的:探讨三磷酸腺苷-氯化镁(ATP-MgCl2)对高氧诱发新生鼠肺损伤的影响。方法:选用生后2天体重5～10 g的Wistar大鼠120只,随机分为空气对照组、高氧模型组、ATP-MgCl2治疗组,每组40只。新生鼠制备成高氧模型后第2天始治疗组新生鼠腹腔内注射ATP-MgCl2(45 mg/kg),空气对照组和高氧模型组腹腔内注射等量生理盐水,以上3组实验开始第3、7及14天每组处死10只动物,取肺组织,光镜下观察肺组织的病理变化,采用免疫组化染色观察肺组织中肿瘤坏死因子-a(TNF-a),转化生长因子(TGF-β1)和波形蛋白(Vimentin)的表达。结果:高氧模型组TNF-a、TGF-β1及Vim-entin表达强度明显高于空气对照组,差异有统计学意义(P<0.01)。ATP-MgCl2组TNF-a、TGF-β1及Vimentin表达强度低于高氧模型组,差异有统计学意义(P<0.05)。结论:三磷酸腺苷-氯化镁对新生大鼠高氧肺损伤有保护作用,对支气管肺发育不良有一定的预防作用。
|
| 关 键 词： | 三磷酸腺苷-氯化镁 高氧 肺损伤 新生大鼠 |
Effect of adenosine triphosphate-magnesium chloride on hyperoxia induced lung injury of neonatal rats |
| |
| YIN Yong-Ri,JIN Zheng-Yong,JIN Mei-Hua.Effect of adenosine triphosphate-magnesium chloride on hyperoxia induced lung injury of neonatal rats[J].Maternal and Child Health Care of China,2011,26(12):1870-1872. |
| |
| Authors: | YIN Yong-Ri JIN Zheng-Yong JIN Mei-Hua |
| |
| Institution: | YIN Yong-Ri,JIN Zheng-Yong,JIN Mei-Hua.Department of Pediatrics,Affiliated Hospital of Yanbian University,Yanji 133000,Jilin,China |
| |
| Abstract: | Objective:To explore the effect of adenosine triphosphate-magnesium chloride(ATP-MgCl2) on hyperoxia induced lung injury of neonatal rats.Methods:120 Wistar rats aged 2 days old whose body weight was 5~10 grams were selected and divided into air control group,hyperoxia model group and ATP-MgCl2 treatment group randomly,40 rats in each group.The neonatal rat models of hyperoxia were established,the neonatal rats in ATP-MgCl2 treatment group were treated with intraperitoneal injection of ATP-MgCl2(45 mg/kg) o... |
| |
| Keywords: | Adenosine triphosphate-magnesium chloride Hyperoxia Lung injury Neonatal rats |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
