| Livin、Smac和Ki67在上皮性卵巢癌中的表达及意义 |
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| 引用本文： | 刘文博,孔红霞.Livin、Smac和Ki67在上皮性卵巢癌中的表达及意义[J].中国妇幼保健,2011,26(12):1875-1878. |
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| 作者姓名： | 刘文博 孔红霞 |
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| 作者单位： | 郑州大学第三附属医院,河南,郑州,450052 |
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| 摘 要： | 目的:探讨凋亡抑制蛋白Livin、凋亡相关因子Smac和细胞增殖核抗原Ki67在上皮性卵巢癌的表达及临床意义,并分析三者的相关性。方法:利用免疫组化SP法检测50例上皮性卵巢癌、20例交界性卵巢肿瘤、20例良性卵巢肿瘤和20例正常卵巢组织中三者的表达情况。结果:Livin与Ki67在卵巢癌中的表达明显高于其他3组(P<0.01),在卵巢组织中的表达与组织病理学分级和有无淋巴结转移呈正相关(P<0.05),与组织学类型、分期无关。Smac在卵巢癌中的表达明显低于其他3组(P<0.01),在卵巢组织中的表达与组织病理学分级和有无淋巴结转移呈负相关(P<0.05),与组织学类型、分期无关。结论:Livin、Smac和Ki67在上皮性卵巢癌的发生、分化、进展过程中起重要作用;Livin、Smac和Ki67有望成为治疗卵巢癌的新靶点。
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| 关 键 词： | Livin Smac ki67 卵巢癌 免疫组化 |
Expressions and significances of Livin,Smac and Ki67 in epithelial ovarian carcinoma |
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| LIU Wen-Bo,KONG Hong-Xia.Expressions and significances of Livin,Smac and Ki67 in epithelial ovarian carcinoma[J].Maternal and Child Health Care of China,2011,26(12):1875-1878. |
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| Authors: | LIU Wen-Bo KONG Hong-Xia |
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| Institution: | LIU Wen-Bo,KONG Hong-Xia.The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China |
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| Abstract: | Objective:To explore the expressions and significances of inhibitor of apoptosis protein-Livin,apoptosis related factor-Smac and proliferating cell nuclear antigen-Ki67 in epithelial ovarian carcinoma,and analyze their correlation.Methods:Immunohistochemical SP method was used to detect the expression levels of Livin,Smac and Ki67 in 50 cases with epithelial ovarian cancer,20 cases with borderline ovarian tumor,20 cases with benign ovarian tumor and 20 cases with normal ovarian tissues.Results:The expressio... |
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| Keywords: | Livin Smac ki67 |
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